Evidence map›Paper›PMID 41938045›Full record

ReviewFrontiers in urology2026

Breaking barriers in male infertility: the power of artificial intelligence-driven solutions.

Laura Ibañez Vazquez, Natalia Pérez Romero, Daniel Tueti Silva, Sarelis Infante, Claudia González-Santander, Irene De La Parra, Isabel Galante Romo, Juan A Gómez Rivas, Jesús Moreno Sierra

Abstract readReview
In one paragraph

Review in Frontiers in urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Laura Ibañez VazquezSan Carlos University Clinical Hospital, Madrid, Spain.
Natalia Pérez RomeroSan Carlos University Clinical Hospital, Madrid, Spain.
Daniel Tueti SilvaSan Carlos University Clinical Hospital, Madrid, Spain.
Sarelis InfanteHospital de Nuestra Señora de Sonsoles, Avila, Spain.
Claudia González-SantanderSan Carlos University Clinical Hospital, Madrid, Spain.
Irene De La ParraHospital Universitario Ramon y Cajal, Madrid, Spain.
Isabel Galante RomoSan Carlos University Clinical Hospital, Madrid, Spain.
Juan A Gómez RivasSan Carlos University Clinical Hospital, Madrid, Spain.
Jesús Moreno SierraSan Carlos University Clinical Hospital, Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infertility is defined as the inability of a sexually active couple, not using contraception, to achieve a spontaneous pregnancy within 12 months. It affects an estimated 8% to 12% of couples worldwide, with 30% to 50% of cases attributable, either primarily or in part, to male factors. Despite the increasing number of assisted reproductive technology (ART) procedures performed globally, improvements in fertilization and pregnancy outcomes have been limited. The need to improve diagnostic accuracy and therapeutic efficiency has driven the development of artificial intelligence (AI) in reproductive medicine. This narrative review aims to explore how AI is transforming the diagnosis and treatment of male infertility. AI technologies are nowadays being used to automate and refine semen analysis, providing more reliable assessments of sperm morphology, motility, and concentration. These innovations enable clinicians to improve the prediction of semen quality and to identify which patients might benefit most from specific interventions, such as sperm retrieval in cases of non-obstructive azoospermia or the selection of optimal sperm cells for reproductive techniques. Moreover, advanced AI algorithms-including support vector machines, deep neural networks, and decision trees-outperform traditional methods, offering greater precision and reducing subjectivity in laboratory evaluations. Additionally, AI is being utilized to estimate the chances of success with assisted reproductive techniques, assess sperm DNA fragmentation, and guide the selection of sperm. The integration of AI into clinical practice not only enables more accessible and personalized diagnoses but also opens new perspectives for the development of individualized treatments, optimizing reproductive outcomes. However, further multicenter validation of AI-based models, methodological standardization, and careful consideration of ethical and privacy issues are necessary before widespread clinical adoption.

Indexed as

artificial intelligencemale infertilitypredictive models of artsemen analysessemen diagnostic evaluation

Identifiers

PMID41938045
PMCPMC13046520

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.