Evidence map›Paper›PMID 41937981›Full record

ArticleJournal of bone and joint infection2026

Combined analysis of host immune response, biofilm genes, and 16S rRNA detection in fracture-related infection: an observational cohort study.

Melissa Depypere, Jonathan Sliepen, Jolien Onsea, Yves Debaveye, T Fintan Moriarty, Elena Della Bella, Emmanuel André, Johan Van Weyenbergh, Willem-Jan Metsemakers

Abstract read
In one paragraph

Article in Journal of bone and joint infection, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Melissa DepypereDepartment of laboratory medicine, University Hospitals Leuven, 3000, Leuven, Belgium.
Jonathan SliepenDepartment of Trauma Surgery, University Medical Center Groningen, Groningen, the Netherlands.
Jolien OnseaDepartment of Trauma Surgery, University Hospitals Leuven, 3000 Leuven, Belgium.ORCID https://orcid.org/0000-0002-5096-5789
Yves DebaveyeDepartment of Intensive Care Medicine, University Hospitals Leuven, Leuven, Belgium.
T Fintan MoriartyAO Research Institute Davos, Davos, Switzerland.ORCID https://orcid.org/0000-0003-2307-0397
Elena Della BellaAO Research Institute Davos, Davos, Switzerland.ORCID https://orcid.org/0000-0001-5151-7390
Emmanuel AndréDepartment of laboratory medicine, University Hospitals Leuven, 3000, Leuven, Belgium.
Johan Van WeyenberghDepartment of Microbiology, Immunology and Transplantation, Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven, Leuven, Belgium.
Willem-Jan MetsemakersDepartment of Trauma Surgery, University Hospitals Leuven, 3000 Leuven, Belgium.ORCID https://orcid.org/0000-0002-4114-9093

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fracture-related infection (FRI) is a serious complication in orthopaedic trauma that can lead to delayed union, nonunion, and poor clinical outcomes. A better understanding of the host immune response may provide valuable insights into the pathophysiology of FRI and may help identify genomic elements that contribute to the infection. This observational study compared immune responses between patients with FRI and non-infected controls using bone/tissue biopsies and sonication fluid, and it explored the possibility of detecting bacterial and biofilm genes using transcriptome profiling with hybridization technology (nCounter

Identifiers

PMID41937981
PMCPMC13044966

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.