Evidence map›Paper›PMID 41937955›Full record

ArticleArthroplasty today2026

Low Preoperative Platelet Count Is Associated With Deep Surgical Site Infection in Knee Arthroplasty.

Jeffrey M Brown, Trevor S Lloyd, Mario Eusebio, Autreen Golzar, Alan Li, Joshua Mehany, Rene F Chun, John S Adams, Michael R Yeaman, Edward J McPherson and 1 more

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In one paragraph

Article in Arthroplasty today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jeffrey M BrownDepartment of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Trevor S LloydDavid Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Mario EusebioDavid Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Autreen GolzarDavid Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Alan LiDavid Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Joshua MehanyUniversity of California, Los Angeles, CA, USA.
Rene F ChunDepartment of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
John S AdamsDepartment of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Michael R YeamanDivisions of Molecular Medicine and Infectious Diseases, Department of Medicine, The Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA, USA.
Edward J McPhersonDepartment of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Nicholas M BernthalDepartment of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Knee arthroplasty (KA) significantly improves pain and function in gonarthrosis. Despite its success, major complications like deep surgical site infection (SSI) remain a concern. Infection treatments often require aggressive protocols, including implant exchange and prolonged antimicrobial therapy, emphasizing the need for preoperative patient optimization to mitigate infection risk. Preoperative platelet count has been proposed as a predictive marker for postoperative infection. Beyond their hemostatic role, platelets possess antimicrobial properties and are considered the first line of defense against microbial proliferation within the surgical site. This database review aims to assess the relationship between preoperative platelet count and deep SSI. Methods: The National Surgery Quality Improvement Program was queried for patients who underwent primary total or unicompartmental KA between 2015 and 2022 and developed deep SSI within 30 days. Postoperative outcomes were analyzed with respect to platelet count as a continuous and categorical variable. Results: Deep SSI was significantly more common in patients with preoperative platelet counts <150,000/ Conclusions: Thrombocytopenia (<150,000 platelets/

Indexed as

Knee arthroplastyPeriprosthetic infectionPlatelet countRisk factorsThrombocytopenia

Identifiers

PMID41937955
PMCPMC13050103

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.