ReviewJournal of ophthalmology2026
Advances in Optical Tissue Clearing for Three-Dimensional Ocular Imaging and Analysis.
Review in Journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Advances in Optical Tissue Clearing for Three-Dimensional Ocular Imaging and Analysis.Journal of ophthalmology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The visualization of tissue architecture has long been constrained by optical absorption and scattering phenomena. Recent advances in optical tissue clearing techniques have revolutionized deep tissue imaging by overcoming these fundamental limitations, enabling high-resolution microscopic examination of intact organ systems. In ophthalmic research, these methodologies provide transformative capabilities for macroscopic three-dimensional visualization, effectively addressing the spatial constraints inherent to conventional two-dimensional histological sections. This paradigm shift has opened new avenues for investigating complex spatial relationships in ocular biology, including vascular network organization, neural connectivity patterns, and dynamic cellular processes. This comprehensive review synthesizes the current literature on tissue clearing methodologies with specific emphasis on ocular applications, systematically examining (1) the unique structural considerations for eye tissue clearing, (2) the established protocols for ocular tissue clearing, (3) the new discoveries in ocular structures through tissue clearing, (4) the imaging acquisition and analysis for cleared eye tissue, and (5) the emerging directions for future technological development. By integrating diverse insights, this review establishes a foundation for the continued refinement of tissue clearing approaches in ocular research, promoting a deeper understanding of eye structure and pathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.