ArticleReports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology2026
Volumetric regression of meningiomas following SRS and hFSRT - insights from long-term analysis.
Article in Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Meningiomas are the most common primary brain tumors in adults, typically managed with surgery, stereotactic radiosurgery (SRS), or hypofractionated stereotactic radiotherapy (hFSRT). While local control rates are high, volumetric regression dynamics and radiobiological parameters remain underexplored. This study evaluates meningioma regression after SRS and hFSRT and estimates the α/β ratio to refine radiotherapy strategies. Materials and methods: A retrospective analysis included 150 patients with intracranial meningiomas treated between 2010-2021. Volumetric assessment was performed for 62 lesions (1-10 cm Results: SRS achieved significantly faster regression, with tumors shrinking by 32.7% at 2 years and 67.4% at 4 years, compared with 15.3% and 31.7% for hFSRT (p = 0.003). The α/β ratio was calculated at 3.15 Gy [95% confidence interval (CI): 3.07-3.23], refining understanding of meningioma radiobiology. Local control reached 91.3%, with comparable outcomes for SRS (91.4%) and hFSRT (91.3%). Symptomatic complications included brain edema (7.9%) and radiation necrosis (2.6%). Conclusion: CyberKnife SRS and hFSRT are effective and safe for meningiomas, though SRS induces faster volumetric regression (19%
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