ArticleThe Annals of otology, rhinology, and laryngology2026
Adjunctive Serum Drops to Paper Patch for Tympanic Membrane Perforation.
Article in The Annals of otology, rhinology, and laryngology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
objectiveTo evaluate the effectiveness of autologous serum drops combined with paper patch myringoplasty in enhancing tympanic membrane (TM) perforation closure among patients with prior patch failure.
methodsThis retrospective chart review included 81 patients with chronic TM perforations unresponsive to initial paper patching. Patients were divided into 2 groups: the experimental group received autologous serum drops alongside secondary paper patching, while the control group received patching alone. The primary outcome was TM closure at 8 weeks. Kaplan-Meier survival analysis and Cox regression were used to evaluate time-to-closure and the effect of patient variables.
resultsClosure rates were significantly higher in the experimental group (54.5%) compared to the control group (21.6%;
conclusionAutologous serum drops significantly improve TM closure rates when added to paper patch myringoplasty, offering a safe, cost-effective, and non-surgical option for managing chronic perforations. Further studies with larger sample sizes and long-term follow-ups are warranted.
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