ArticleVeterinary dermatology2026
Epidemiology of Canine Cutaneous Histiocytoma: Insights From Age and Topographic Clustering.
Article in Veterinary dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
backgroundCanine cutaneous histiocytoma (CCH) is a benign Langerhans-cell tumour that often regresses spontaneously via inflammation.
objectivesTo estimate incidence and characterise age and breed-anatomical-site patterns using two complementary clustering analyses. MATERIALS AND
methodsA total of 359 histopathologically-confirmed CCHs from a private veterinary laboratory in Portugal (January 2020-January 2022) were analysed with dog-population denominators from the national registry (SIAC). Incidence rates (IR) were calculated for Lisbon-Setúbal; breed- and sex-specific relative risks (RR) were estimated. Age was modelled with BIC-selected Gaussian mixtures; breed-site patterns were summarised by hierarchical clustering of site frequencies (heatmaps).
resultsCases concentrated in young dogs (≤ 2 years, 48.8%) and males (58.5%). Age clustering defined three bands (≈ ≤ 1.5, 1.5-3.5, > 3.5 years) with differing breed and site distributions. Breed-site clustering revealed recurring anatomical predilections by breed and sex. The annual IR in Lisbon-Setúbal was 4.0 per 10,000 dogs (3.5 in females; 4.4 in males). Risk was highest in French bulldogs (RR 11.5; IR 34.1) and Boxers (RR 8.3; IR 24.5) versus mixed-breed dogs (p < 0.001). CONCLUSIONS AND CLINICAL RELEVANCE: Canine cutaneous histiocytoma (CCH) shows clear age bands and breed-linked anatomical predilections; these patterns help prioritise ages, sites and breeds for studies of inflammation-mediated regression.
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