ArticleNano letters2026
Hydration-Mediated Energy Landscapes Govern Rotational Flexibility in Membrane-Bound Annexin V Assemblies.
Article in Nano letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interfacial water organization and dynamics govern protein stability and function across molecular to supramolecular scales. Annexin V (AnxA5), a membrane repair protein, forms 2D assemblies on lipid membranes, yet the hydration role in repair remains unexplored. Combining three-dimensional atomic force microscopy (3D-AFM) and molecular dynamics (MD) simulations, we resolve the 3D hydration architecture of AnxA5 assemblies at molecular resolution. AnxA5 is enveloped by a continuous, nonlayered hydration network extending 1.5-2 nm into bulk solvent, exhibiting quasi-periodic lateral organization across crystalline and noncrystalline trimer domains. MD simulations indicate this network forms dynamic hydrogen-bonded bridges that may stabilize interdomain junctions, thereby modulating the local energy landscape. This hydration-dependent configurational flexibility, coupled with thermal fluctuations, drives stochastic, reversible trimer rotation, potentially modulating membrane interactions and Ca
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.