Evidence map›Paper›PMID 41937362›Full record

ArticleNeurorehabilitation and neural repair2026

Mapping Brain Function After Stroke: From Early Disorganization to Late Compensation.

Célia Delcamp, Zhibin Zhou, Ramesh Srinivasan, Steven C Cramer

Abstract read
In one paragraph

Article in Neurorehabilitation and neural repair, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Célia DelcampDepartment of Neurology, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-2303-0769
Zhibin ZhouDepartment of Cognitive Sciences, University of California Irvine, Irvine, CA, USA.
Ramesh SrinivasanDepartment of Cognitive Sciences, University of California Irvine, Irvine, CA, USA.
Steven C CramerDepartment of Neurology, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-6214-6211

Funding

Validation of Early Prognostic Data for Recovery Outcomes after Stroke for Future, Higher Yield Trials (VERIFY)U01NS120910 · NINDS · YALE UNIVERSITY · PI Steven C. Cramer, Pooja Khatri · 2021 to 2026
$13.5M
Motor Recovery through Plasticity-Inducing Cortical StimulationUH3NS121565 · NINDS · UNIVERSITY OF WASHINGTON · PI Steven C. Cramer, Jeffrey G Ojemann · 2022 to 2026
$4.5M
Telerehabilitation In The Home After Stroke: A Randomized, Controlled, Assessor-Blind Clinical Trial (The TR-2 Trial)UH3NS133283 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CRAMER, STEVEN C., EDWARDS, DYLAN JAMES · 2025 to 2025
$4.5M
Telerehabilitation In The Home After Stroke: A Randomized, Controlled, Assessor-Blind Clinical Trial (The TR-2 Trial)UG3NS133283 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CRAMER, STEVEN C., EDWARDS, DYLAN JAMES · 2024 to 2024
$4.4M
NINDS NIH HHS U01 NS120910NINDS NIH HHS UG3 NS133283NINDS NIH HHS UH3 NS121565NINDS NIH HHS UH3 NS133283
6 · The paper itself

Abstract

IntroductionElectroencephalography (EEG) is useful to capture changes in brain function after stroke. How these relate to time after stroke and deficit severity remains unclear. We examined these issues by testing specific hypotheses using cortical power and functional connectivity.MethodsThis cross-sectional study included 100 stroke patients and 45 healthy controls. Cortical power and connectivity (coherence) were extracted from a 3-minute resting-state dense-array (256-lead) EEG. Analysis included subgroups based on time post-stroke (<or≥ 90 days) and motor status (Fugl-Meyer score ≤or> 40) using robust permutation tests and partial Spearman's correlations.ResultsEarly after stroke, power was supranormal in low frequency bands and subnormal in high frequency bands, while brain connectivity was widely subnormal. With greater time post-stroke, beta and gamma connectivity were higher bilaterally, and brain connectivity was supranormal in the late phase across all frequency bands. Motor status was related to cortical power only in cortico-subcortical patients and was related to connectivity in a manner that varied according to severity of motor deficit and lesion location.ConclusionsResults support use of EEG measures as biomarkers of brain reorganization after stroke and emphasize the need for a nuanced understanding according to individual details. Current findings indicate that motor deficits are best understood using a network connectivity approach and highlight the need to interpret EEG measures post-stroke within the specific context (time post-stroke, deficit severity, and lesion location) in which they are acquired to maximize their utility as biomarkers to guide personalized rehabilitation.

Indexed as

BrainBrain MappingBrain WavesStrokeAdultAgedCross-Sectional StudiesElectroencephalographyFemaleHumansMaleMiddle Agedcoherenceelectroencephalographyfunctional connectivitymotor statusneuroplasticityresting-state

Identifiers

PMID41937362
PMCPMC13055745

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.