Visible-Light Sensitized Isomerization in the Lipid Bilayer Enables Activation of a Transmembrane Transporter.

Julia Villalva, Abhishek Mondal, Willem Marulanda, Jasper E Bos, Sylvestre Bonnet, Anjali Pandit, Sander J Wezenberg

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Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

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1 citing paper in PubMed.

Multi-wavelength photo-activation of transmembrane chloride transport in distinct vesicle populations using photocaged indolocarbazole anionophores.Chemical science · 2026
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Authors and funding

7 authors.

Julia VillalvaLeiden Institute of Chemistry, Leiden University, CC Leiden, The Netherlands.

Abhishek MondalLeiden Institute of Chemistry, Leiden University, CC Leiden, The Netherlands.

Willem MarulandaLeiden Institute of Chemistry, Leiden University, CC Leiden, The Netherlands.

Jasper E BosLeiden Institute of Chemistry, Leiden University, CC Leiden, The Netherlands.

Sylvestre BonnetLeiden Institute of Chemistry, Leiden University, CC Leiden, The Netherlands.ORCID 0000-0002-5810-3657

Anjali PanditLeiden Institute of Chemistry, Leiden University, CC Leiden, The Netherlands.

Sander J WezenbergLeiden Institute of Chemistry, Leiden University, CC Leiden, The Netherlands.ORCID 0000-0001-9192-3393

Funding

European Research Council 802830HORIZON-MSCA-PF program 101108077Netherlands Organization for Scientific research

6 · The paper itself

Abstract

Currently, there is major interest in embedding light-responsive (supra)molecular systems in phospholipid bilayer membranes, for example, to control transmembrane transport processes. Most of these systems are operated by harmful UV-light. Although in solution phase the isomerization of photoswitchable systems has been achieved using visible-light-absorbing photosensitizers, no cases are known yet of sensitized isomerization in a lipid bilayer environment. Herein, we show that the active isomer of a stiff-stilbene based chloride transporter can be generated in situ by irradiation and energy transfer from a ruthenium tris(bipyridyl) complex. In the bilayer, this process is more efficient than in solution, as a benefit of the higher effective concentration of sensitizer and transporter upon confinement. Our work offers an approach to induce isomerization of membrane-embedded systems by visible light, without the need of synthetic modification and loss of function or activity.

Indexed as

LightLipid BilayersIsomerismStilbenesLipid BilayersStilbenesanion transportlipid bilayersmolecular switchesphotosensitizationstiff‐stilbene

Identifiers

PMID41937324

DOI10.1002/anie.6015167

PMCPMC13159413

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