ArticleMedical physics2026
Direct estimation of activity concentration in regional voxels with application to
Article in Medical physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundQuantitative SPECT in radionuclide-therapy is limited by partial-volume effects (PVEs). The implementation of regional voxels (r.v.), estimating mean activity concentrations in regions directly from projections, offers a promising alternative for the geometry-specification to reduce PVEs. PURPOSE: This study aims to demonstrate that activity-concentration estimation with r.v. is superior to reconstruction with cuboid voxels (cu.v.) with post-reconstruction partial-volume correction (PVC) for estimation of activity concentration in
methodsData originated from one patient administered [
resultsFor both patient and simulated data, activity concentrations estimated with r.v. are higher than those from cu.v., with comparable standard deviations. Mean relative errors for simulated images from PA relative to simulation input at 1 d p.i. reconstructions with r.v. are (-4.6 ± 1.4) %, (3.0 ± 0.5) %, (0.1 ± 0.5) %, and (5.6 ± 1.2) % for tumor, left kidney, right kidney, and spleen, respectively. Corresponding results for cu.v. with post-reconstruction PVC are (-12.3 ± 2.2) %, (-4.2 ± 0.6) %, (-7.0 ± 0.5) %, and (-2.1 ± 1.1) %. For simulated images based on PB, the mean relative errors obtained for r.v. are (-3.1 ± 3.5) %, (1.2 ± 1.2) %, (-1.7 ± 1.1) %, and (2.3 ± 0.8) %, while for cu.v. with PVC they are (-7.9 ± 6.7) %, (-5.8 ± 1.9) %, (-9.0 ± 1.0) %, and (-0.7 ± 2.6) %.
conclusionsRegional voxels are superior to cu.v. for estimation of the activity concentration in organs in
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