Evidence map›Paper›PMID 41937257›Full record

Observational studyPediatric transplantation2026

Immunogenicity and Safety of Live Attenuated Varicella Vaccine in Children and Youth With Solid Organ Transplants in Canada: A Canadian Immunization Research Network Study.

Catherine Burton, Jo Lin Chew, Manish Sadarangani, Tom Blydt-Hansen, Soren Gantt, Shaun K Morris, Sneha Suresh, Anne Pham-Huy, Anthony Otley, Bruce Tapiero and 7 more

Abstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Pediatric transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Catherine BurtonDepartment of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0002-8361-5582
Jo Lin ChewDepartment of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Manish SadaranganiVaccine Evaluation Center, BC Children's Hospital Research Institute, Vancouver, Canada.
Tom Blydt-HansenVaccine Evaluation Center, BC Children's Hospital Research Institute, Vancouver, Canada.ORCID 0000-0002-8864-0197
Soren GanttCentre de Recherche Azrieli du Centre Hospitalier Universitaire de Ste-Justine et Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, Canada.
Shaun K MorrisDivision of Infectious Diseases and Child Health Evaluative Sciences, Hospital for Sick Children and Department of Pediatrics, University of Toronto, Toronto, Canada.
Sneha SureshDepartment of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0003-0456-1860
Anne Pham-HuyDepartment of Pediatrics, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, Canada.
Anthony OtleyDepartment of Pediatrics, IWK Health Centre, Dalhousie University, Halifax, Canada.
Bruce TapieroCentre Hospitalier Universitaire de Ste-Justine, Université of Montréal, Montreal, Canada.
Hana MitchellVaccine Evaluation Center, BC Children's Hospital Research Institute, Vancouver, Canada.
Juthaporn CowanDepartment of Medicine, University of Ottawa at the Ottawa Hospital, Ottawa, Canada.ORCID 0000-0001-6648-5109
Aida SivroNational Microbiology Laboratory Branch, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.
Pierre-Philippe Piché-RenaudDivision of Infectious Diseases and Child Health Evaluative Sciences, Hospital for Sick Children and Department of Pediatrics, University of Toronto, Toronto, Canada.ORCID 0000-0003-4632-6877
Jeannette L ComeauDepartment of Pediatrics, IWK Health Centre, Dalhousie University, Halifax, Canada.
Karina A TopDepartment of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Special Immunization Clinic Investigators

Funding

BC Children's HospitalBig Gifts for Little LivesCanadian Donation and Transplantation Research ProgramCanadian Immunization Research NetworkCIHRPublic Health Agency of CanadaThe Addison Fund of the Organ Donation and Transplant Research Foundation of British Columbia
6 · The paper itself

Abstract

introductionChildren with solid organ transplants (SOT) face higher risks of severe disease from varicella-zoster virus (VZV). Although some guidelines recommend live attenuated varicella vaccine (LAVV) for select children post SOT, further real-world vaccine immunogenicity and safety data are needed.

methodsA prospective observational study was conducted at 4 Canadian centres from 2020 to 2023. Children who were 1-19 years, VZV IgG negative, > 1 year post liver, kidney, or heart transplant, and were receiving LAVV as part of clinical care in accordance with centre-specific criteria were eligible for inclusion. Measurement of VZV IgG was recommended post-vaccination with LAVV. Adverse events following immunization (AEFIs) were captured via telephone survey and chart review.

resultsFifty-six pediatric SOT recipients (51 liver, 3 kidney, and 2 heart) received ≥ 1 dose of LAVV. Serology after the last post-transplant dose of LAVV was available for 43/56 (77%) participants; 39/43 (91%) seroconverted to positive VZV IgG (12/16 after 1 post-transplant dose, 26/30 after 2 doses and 1/1 after 3 doses). Among 56 dose 1 recipients, 6 (11%) experienced an AEFI requiring medical attention. Four had rash: 3 with varicella-like rash (1/3 confirmed vaccine-strain varicella) and none required antivirals. Two had acute rejection 4-5 weeks after LAVV. Two of 38 (5%) dose 2 recipients had an AEFI requiring medical attention, with one serious AEFI 7 weeks after LAVV that was not deemed vaccine-related after careful review.

conclusionsLAVV was immunogenic and generally well tolerated in our cohort of patients. Post-SOT LAVV should be considered for select VZV seronegative children with close follow-up.

Indexed as

ChickenpoxChickenpox VaccineImmunogenicity, VaccineOrgan TransplantationAdolescentCanadaChildChild, PreschoolFemaleHumansInfantMaleProspective StudiesVaccines, AttenuatedChickenpox VaccineVaccines, Attenuatedlive viral vaccinespediatricsolid organ transplantvaricella

Identifiers

PMID41937257
PMCPMC13051050

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.