Evidence map›Paper›PMID 41937204›Full record

ArticleBMC plant biology2026

Genome-wide identification of the MCA gene family and its role in resistance to powdery mildew in wheat.

Ping Hu, Xinjie Zhu, Jun Xu, Lu Zhang, Kaige Zhou, Haiyan Hu, Chengwei Li

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Article in BMC plant biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Ping HuCollege of Agriculture/State Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, Henan Institute of Science and Technology, Xinxiang, China. huping@hist.edu.cn.
Xinjie ZhuCollege of Agriculture/State Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, Henan Institute of Science and Technology, Xinxiang, China.
Jun XuCollege of Horticulture and Landscape Architecture, Henan Institute of Science and Technology, Xinxiang, China.
Lu ZhangCollege of Agriculture/State Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, Henan Institute of Science and Technology, Xinxiang, China.
Kaige ZhouCollege of Agriculture/State Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, Henan Institute of Science and Technology, Xinxiang, China.
Haiyan HuCollege of Agriculture/State Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, Henan Institute of Science and Technology, Xinxiang, China. haiyanhuhhy@126.com.
Chengwei LiCollege of Agriculture, Zhengzhou University, Zhengzhou, China. lcw3366@zzu.edu.cn.

Funding

Basic Research Special Project of Key Research Projects in Higher Education Institutions of Henan Province No. 24ZX013Henan Provincial Science and Technology Research Project No. 252102110290National Natural Science Foundation of China No. 31901538
6 · The paper itself

Abstract

backgroundMetacaspases (MCAs) play important roles in regulating plant growth and development, as well as programmed cell death under stress conditions.

resultsBased on whole-genome information, a total of 36, 10, 12, 23, 11, nine, nine, six, eight, and five MCA genes were identified in Triticum aestivum, Hordeum vulgare, Triticum urartu, Triticum dicoccoides, Aegilops tauschii, Oryza sativa, Arabidopsis thaliana, Vitis vinifera, Solanum lycopersicum, and Cucumis sativus, respectively. The gene structures, evolutionary relationships, and potential roles of TaMCAs in wheat powdery mildew resistance were systematically analyzed. Phylogenetic analysis classified MCAs into four subgroups (Class I-1, I-2, II-1, and II-2), with members within the same subgroup exhibiting highly similar gene structures. Notably, two pairs of tandemly duplicated genes (TaMCA1A-2/TaMCA1A-3 and TaMCA1B-2/TaMCA1B-3) were identified in wheat. Virus-induced gene silencing and qRT-PCR demonstrated that TaMCA4D-3, as a Class I-2 gene, positively regulates resistance to wheat powdery mildew, and subcellular localization analysis indicated that TaMCA4D-3 is localized in both the nucleus and cytoplasm.

conclusionsCollectively, these findings provide new insights into the classification and evolutionary relationships of the MCA gene family across plant species and elucidate the role of MCAs in wheat resistance to powdery mildew.

Indexed as

AscomycotaDisease ResistancePlant DiseasesPlant ProteinsTriticumGenes, PlantGenome, PlantMultigene FamilyPhylogenyPlant ProteinsGene expressionMCA gene familyPowdery mildewVirus-induced gene silencingWheat

Identifiers

PMID41937204
PMCPMC13188564

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