ArticleBiophysical reports2026
Effect of the gut microbiota metabolite phenylacetylglycine on cardiac Ca
Article in Biophysical reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Gut microbiota-derived metabolites in cardiovascular disease: mechanisms, disease-specific roles, and translational opportunities.Frontiers in cardiovascular medicine · 2026Review
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- Update of
Authors and funding
2 authors.
Funding
Abstract
Phenylacetylglutamine (PAGln) and phenylacetylglycine (PAGly) are small molecules derived from the metabolism of phenylalanine by gut microbiota. Elevated levels of PAGln and PAGly in serum have been associated with increased risks for cardiovascular diseases. It has been suggested that PAGln and PAGly reduce cardiac contraction by blunting the adrenergic response during sympathetic stimulation. However, little is known about whether the effect of PAGln and PAGly on the heart function is associated with an alteration of intracellular Ca
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.