Evidence map›Paper›PMID 41936816›Full record

Observational studyAcademic pediatrics2026

School Difficulties and Long COVID in Children and Adolescents.

Harrison T Reeder, Lawrence C Kleinman, Melissa S Stockwell, Tanayott Thaweethai, Deepti B Pant, Kyung E Rhee, Terry L Jernigan, Jessica N Snowden, Amy L Salisbury, Patricia A Kinser and 11 more

Abstract readObservational Study
In one paragraph

Observational study in Academic pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Harrison T ReederMassachusetts General Hospital Biostatistics (HT Reeder, T Thaweethai, DB Pant, A Krishnamoorthy, and AS Foulkes), Somerville, Mass; Department of Medicine (HT Reeder, T Thaweethai, and AS Foulkes), Harvard Medical School, Boston, Mass. Electronic address: hreeder@mgh.harvard.edu.
Lawrence C KleinmanDivision of Population Health (LC Kleinman), Quality, and Implementation Sciences (PopQuIS), Department of Pediatrics, Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ; Child Health Institute of New Jersey (LC Kleinman), Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ; Bristol Myers Squibb Children's Hospital (LC Kleinman), New Brunswick, NJ.
Melissa S StockwellDivision of Child and Adolescent Health (MS Stockwell), Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY; Department of Population and Family Health (MS Stockwell), Mailman School of Public Health, New York-Presbyterian Hospital, New York, NY; NewYork-Presbyterian Hospital (MS Stockwell and JD Milner), New York, NY.
Tanayott ThaweethaiMassachusetts General Hospital Biostatistics (HT Reeder, T Thaweethai, DB Pant, A Krishnamoorthy, and AS Foulkes), Somerville, Mass; Department of Medicine (HT Reeder, T Thaweethai, and AS Foulkes), Harvard Medical School, Boston, Mass.
Deepti B PantMassachusetts General Hospital Biostatistics (HT Reeder, T Thaweethai, DB Pant, A Krishnamoorthy, and AS Foulkes), Somerville, Mass.
Kyung E RheeDivision of Child and Community Health (KE Rhee), Department of Pediatrics, UC San Diego School of Medicine, La Jolla, Calif.
Terry L JerniganDepartments of Cognitive Science (TL Jernigan), Psychiatry, and Radiology, and Center for Human Development, University of California, San Diego, Calif.
Jessica N SnowdenDivision of Infectious Diseases (JN Snowden), Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Ark.
Amy L SalisburySchool of Nursing (AL Salisbury and PA Kinser), Virginia Commonwealth University, Richmond, Va.
Patricia A KinserSchool of Nursing (AL Salisbury and PA Kinser), Virginia Commonwealth University, Richmond, Va.
Joshua D MilnerNewYork-Presbyterian Hospital (MS Stockwell and JD Milner), New York, NY; Division of Allergy (JD Milner), Immunology and Rheumatology, Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY.
Kelan G TantisiraDivision of Respiratory Medicine (KG Tantisira), Department of Pediatrics, UC San Diego School of Medicine, Rady Children's Hospital, San Diego, Calif.
David WarburtonChildren's Hospital Los Angeles (D Warburton), Keck School of Medicine, University of Southern California, Los Angeles, Calif.
Sindhu MohandasDivision of Infectious Diseases (S Mohandas), Department of Pediatrics, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, Calif.
John C WoodDivision of Cardiology (JC Wood), Department of Pediatrics, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, Calif.
Megan L FitzgeraldRECOVER Patient, Caregiver, or Community Advocate Representative (ML Fitzgerald and M Carmilani), New York, NY; Patient Led Research Collaborative (ML Fitzgerald), Calabasas, Calif.
Megan CarmilaniRECOVER Patient, Caregiver, or Community Advocate Representative (ML Fitzgerald and M Carmilani), New York, NY; Long Covid Families (M Carmilani), Charlotte, NC.
Aparna KrishnamoorthyMassachusetts General Hospital Biostatistics (HT Reeder, T Thaweethai, DB Pant, A Krishnamoorthy, and AS Foulkes), Somerville, Mass.
Andrea S FoulkesMassachusetts General Hospital Biostatistics (HT Reeder, T Thaweethai, DB Pant, A Krishnamoorthy, and AS Foulkes), Somerville, Mass; Department of Medicine (HT Reeder, T Thaweethai, and AS Foulkes), Harvard Medical School, Boston, Mass; Department of Biostatistics (AS Foulkes), Harvard T.H. Chan School of Public Health, Boston, Mass.
Rachel S GrossDivision of General Pediatrics (RS Gross), Department of Pediatrics, NYU Grossman School of Medicine, New York, NY. Electronic address: Rachel.Gross@nyulangone.org.
RECOVER-Pediatrics Consortium

Funding

ACTIV Integration of Host-targeting Therapies for COVID-19 Administrative Coordinating CenterOT2HL156812 · NHLBI · RESEARCH TRIANGLE INSTITUTE · PI NOLEN, TRACY L, THOMAS, SONIA M · 2020 to 2024
$1270.7M
OTA-21-015A Post-Acute Sequelae of SARS-CoV-2 Infection Initiative: NYU Langone Health Clinical Science Core, Data Resource Core, and PASC Biorepository CoreOT2HL161847 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GROSS, RACHEL SHARON, HORWITZ, LEORA · 2021 to 2025
$651.0M
Interactive Data Portals and Robust Analytic Tools to Wrap PASC Cohorts (iDRAW) OTA-21-015AOT2HL161841 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI FOULKES, ANDREA S, KARLSON, ELIZABETH W · 2021 to 2024
$182.2M
ABCD-USA Consortium: Coordinating CenterU24DA041147 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDRA A BROWN, TERRY L. JERNIGAN · 2015 to 2026
$54.7M
ABCD-USA Consortium: Data Analysis, Informatics and Resource CenterU24DA041123 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE · 2015 to 2026
$51.5M
Adolescent Substance Use Initiation: Disentangling neurocognitive risks from consequences using longitudinal and genetically-informed methodsU01DA041120 · NIDA · UNIVERSITY OF MINNESOTA · PI Monica Luciana, Sylia Wilson · 2015 to 2026
$34.5M
ABCD-USA Consortium: Research ProjectU01DA041089 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Joanna Jacobus, Susan F. Tapert · 2015 to 2026
$31.7M
Prospective Research Studies of Maturation (PRISM)- Research ProjectU01DA041134 · NIDA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ERIN MCGLADE, PERRY FRANKLIN RENSHAW · 2015 to 2026
$29.2M
ABCD-USA CONSORTIUM: RESEARCH PROJECTU01DA041048 · NIDA · CHILDREN'S HOSPITAL OF LOS ANGELES · PI Megan Marie Herting, ELIZABETH R SOWELL · 2015 to 2026
$28.7M
ABCD-USA Consortium: Research ProjectU01DA041106 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mary M Heitzeg, Chandra Sekhar Sripada · 2015 to 2026
$24.9M
FIU-ABCD: Pathways and Mechanisms to Addiction in the Latino Youth of South FloridaU01DA041156 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI Raul Gonzalez, Angela R Laird · 2015 to 2026
$22.8M
ABCD-USA Consortium: Research ProjectU01DA041148 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Damien A Fair, Rebekah S Huber · 2015 to 2026
$22.3M
NHLBI NIH HHS OT2 HL156812NHLBI NIH HHS OT2 HL161841NHLBI NIH HHS OT2 HL161847NIDA NIH HHS U01 DA041022NIDA NIH HHS U01 DA041025NIDA NIH HHS U01 DA041028NIDA NIH HHS U01 DA041048NIDA NIH HHS U01 DA041089NIDA NIH HHS U01 DA041093NIDA NIH HHS U01 DA041106NIDA NIH HHS U01 DA041117NIDA NIH HHS U01 DA041120NIDA NIH HHS U01 DA041134NIDA NIH HHS U01 DA041148NIDA NIH HHS U01 DA041156NIDA NIH HHS U01 DA041174NIDA NIH HHS U01 DA050987NIDA NIH HHS U01 DA050988NIDA NIH HHS U01 DA050989NIDA NIH HHS U01 DA051016NIDA NIH HHS U01 DA051018NIDA NIH HHS U01 DA051037NIDA NIH HHS U01 DA051038NIDA NIH HHS U01 DA051039NIDA NIH HHS U24 DA041123NIDA NIH HHS U24 DA041147
6 · The paper itself

Abstract

objectivePediatric Long COVID (LC) is an infection-associated chronic condition following SARS-CoV-2 infection. While research has begun to elucidate clinical phenotypes, functional impacts are not well described.

methodsCross-sectional data from the NIH-funded Researching COVID to Enhance Recovery (RECOVER) pediatric observational cohort were analyzed to assess associations in school-age children (6 to 11 years) and adolescents (12 to 17 years) between LC and caregiver-reported school-related functional outcomes. LC was defined using RECOVER age group-specific symptom-based LC research indices. The primary outcome was worsening of child grades. Secondary outcomes included difficulty paying attention, limited fun with friends, and having an Individualized Education Program (IEP). Using age-stratified analyses, children with and without LC were matched based on age, sex, and dates of infection and enrollment, to estimate risk ratios (RRs) between LC and each outcome.

resultsThe cohort included 1976 children (406 school-age, 1570 adolescent). About 18% of school-age children and 29% of adolescents with LC had reported worsened grades, compared to 7% and 11% without LC, respectively [school-age: adjusted RR 2.18 (95% CI: 1.15-4.11); adolescent: adjusted RR 2.39 (95% CI: 1.86-3.06)]. In both age groups, children with LC were more likely to have difficulty paying attention, limited fun with friends, and IEPs.

conclusionsLC in school-age children and adolescents was negatively associated with functional school-related outcomes, including academic performance, attention, and peer interactions. As LC affects a substantial proportion of U.S. children, these findings highlight the urgent need to develop, provide, and evaluate school-related services for children and adolescents with LC.

Indexed as

Post-Acute COVID-19 SyndromeAdolescentChildCross-Sectional StudiesFemaleHumansMaleSARS-CoV-2infection-associated chronic conditionlong covidschool performance

Identifiers

PMID41936816
PMCPMC13386493

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.