Evidence map›Paper›PMID 41936458›Full record

ArticleInternational wound journal2026

Early Prediction of Scar Outcomes: A Prospective Study on the Predictive Value of 3-Month Scar Assessments for 12-Month Results.

Rena A Li, Antoinette T Nguyen, Bradley A Melnick, Kelly C Ho, Madeline J O'Connor, Chad M Teven, Thomas A Mustoe, Robert D Galiano

Abstract read
In one paragraph

Article in International wound journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rena A LiNorthwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Antoinette T NguyenUniversity of Rochester School of Medicine and Dentistry, Rochester, New York, USA.ORCID https://orcid.org/0009-0003-3375-3818
Bradley A MelnickWest Virginia School of Osteopathic Medicine, Lewisburg, West Virginia, USA.
Kelly C HoNorthwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Madeline J O'ConnorNorthwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Chad M TevenNorthwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Thomas A MustoeNorthwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Robert D GalianoNorthwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0001-9552-6483

Funding

Crown Family Philanthropies
6 · The paper itself

Abstract

Scar outcomes are traditionally evaluated at 12 months post-surgery, yet early prediction of long-term scar characteristics may facilitate timely interventions, enhance treatment strategies, shorten clinical trial durations, and improve patient outcomes. This study evaluates whether 3-month scar assessments reliably predict 12-month outcomes using validated scar assessment scales and interrater reliability measures. Two surgeons evaluated a prospective cohort of 40 surgical patients using standardised scar assessment tools. Logistic regression assessed the predictive value of 3-month classifications for 12-month binary outcomes ('good' vs. 'poor' scar quality), while linear regression evaluated continuous scar scores. Receiver operating characteristic (ROC) curves and area under the curve (AUC) values quantified predictive accuracy. Scars classified as 'good' at 3 months were significantly more likely to remain 'good' at 12 months (p < 0.001), with strong predictive performance (AUC = 0.763). Linear regression demonstrated significant predictive accuracy for width, height, and overall opinion. However, vascularity predictions were weak, and depth was not significantly associated with long-term outcomes. Interrater reliability was moderate to good across measures, with intraclass correlation coefficients values ranging from 0.215 (depth) to 0.714 (width), and Cohen's Kappa for binary scar classifications of 0.505 (p < 0.001). Early 3-month scar assessments reliably predict 12-month outcomes for width, height, and overall opinion, while vascularity and depth remain less predictable. Scars rated as 'good' at 3 months are unlikely to worsen, while 'poor' scars rarely improve without intervention. These findings highlight the utility of early scar evaluations in guiding postoperative management and patient counselling.

Indexed as

CicatrixWound HealingAdultAgedFemaleHumansMaleMiddle AgedPredictive Value of TestsProspective StudiesReproducibility of ResultsROC CurveTime Factorsprospective analysisscar outcomesscar predictabilityscarring

Identifiers

PMID41936458
PMCPMC13052222

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.