ArticleAlcohol and alcoholism (Oxford, Oxfordshire)2026
Morbidity and mortality in alcohol use disorder: the role of comorbid substance use disorder, age, sex, and the A1 allele of the Taq1A (rs1800497) polymorphism in the ANKK1 gene in an 18-year follow-up.
Article in Alcohol and alcoholism (Oxford, Oxfordshire), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
BACKGROUND AND
aimsThe present study aimed to: (i) compare a patient group with solely alcohol use disorder (AUD) to a group with poly-substance use disorder (poly-SUD) regarding sociodemographic background, morbidity, mortality, and the prevalence of the A1 allele of the Taq1A polymorphism. (ii) Investigate whether gender, age, poly-SUD, and the prevalence of the A1 allele or interactions among these factors, are associated with mortality risk over an 18-year follow-up period.
methodsThis study comprised 360 individuals treated for severe alcohol withdrawal symptoms in 1997 at a treatment unit in Sweden. Genotyping was performed during their hospital stay, and participants were followed annually for up to 18 years using data from Swedish registers.
resultsFifty-three percent of the participants had died over the 18 year period. Poly-SUD patients exhibited higher rates of psychiatric disorders, gastrointestinal diseases, and intoxication as the primary diagnosis. Patients with AUD exhibited a higher prevalence of cardiac diseases. Traumatic causes of death were more prevalent in the poly-SUD group, whereas somatic diseases were more common among individuals with AUD. Male sex and age were the strongest predictors of premature death among individuals with AUD. The A1 allele of the Taq1A polymorphism showed a borderline association with an increased hazard of death.
conclusionsMale sex and age are the strongest predictors of premature death. Patients with poly-SUD may represent a distinct subgroup with different comorbidities and causes of death. To determine whether there is a genetic vulnerability as indicated by the findings, research using larger samples with sufficient statistical power is needed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.