Evidence map›Paper›PMID 41936014›Full record

ArticleClinical and experimental nephrology2026

Spectrum of biopsy-proven kidney diseases in 3514 patients at a single center in Northwest China from 2014 to 2023.

Wenjun Zhang, Lili Zhang, Yingying Wang, Haijuan Tian, Ranhao Li, Hongxia Mai, Hong Shu, Juanli Wang, Ya Wang, Yuke Kong

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Article in Clinical and experimental nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Wenjun Zhang *Nephrology Department, Lanzhou University Second Hospital, No. 82, Cuiyingmen, Lanzhou, China. Zhangwenjun19@lzu.edu.cn.
Lili Zhang *Nephrology Department, Lanzhou University Second Hospital, No. 82, Cuiyingmen, Lanzhou, China.
Yingying WangNephrology Department, Lanzhou University Second Hospital, No. 82, Cuiyingmen, Lanzhou, China.
Haijuan TianNephrology Department, Lanzhou University Second Hospital, No. 82, Cuiyingmen, Lanzhou, China.
Ranhao LiNephrology Department, Lanzhou University Second Hospital, No. 82, Cuiyingmen, Lanzhou, China.
Hongxia MaiNephrology Department, Lanzhou University Second Hospital, No. 82, Cuiyingmen, Lanzhou, China.
Hong ShuNephrology Department, Lanzhou University Second Hospital, No. 82, Cuiyingmen, Lanzhou, China.
Juanli WangNephrology Department, Lanzhou University Second Hospital, No. 82, Cuiyingmen, Lanzhou, China.
Ya WangNephrology Department, Lanzhou University Second Hospital, No. 82, Cuiyingmen, Lanzhou, China.
Yuke KongNephrology Department, Lanzhou University Second Hospital, No. 82, Cuiyingmen, Lanzhou, China.

Funding

Cuiying Scientific and technological Innovation Program of the Second Hospital & Clinical Medical School, Lanzhou university Cy2023-MS-A08
6 · The paper itself

Abstract

backgroundThe manifestations of renal diseases that precede CKD vary among populations and have changed over time. We investigated biopsy-proven renal diseases in patients from Northwest China over a 10-year period.

methodsWe retrospectively analyzed data from 3514 renal biopsies performed at our center from January 2014 to December 2023 and compared the presentations (indications for biopsy) and clinicopathological diagnoses during two periods: 2014-2018 vs. 2019-2023.

resultsOverall, primary glomerulonephritis (PGN) was the most common pathology (72.23%), followed by secondary glomerulonephritis (SGN, 21.35%), and tubulointerstitial diseases (2.79%). Membranous nephropathy (MN, 26.60%) and IgA nephropathy (IgAN, 24.02%) were the main diagnoses in patients with PGN. The proportion of PGN patients with MN and IgAN was greater during the latter period, but the proportion of those with focal segmental glomerular sclerosis was greater during the earlier period (all P < 0.05). Among SGN patients during the later period, the proportion of those with lupus nephritis (LN) and Henoch-Schönlein purpura nephritis (HSPN) was lower and proportion of those with diabetic nephropathy (DN) was greater (all P < 0.05).

conclusionThis descriptive study in Northwest China showed that NS was the main indication for renal biopsy, PGN was the most common diagnosis, and MN was the predominant type of PGN. The proportions of MN and DN were greater in 2019-2023 than in 2014-2018, but the proportions of LN and HSPN had the opposite pattern. These results provide a foundation for future studies that seek to prevent CKD and improve patient outcomes.

Indexed as

KidneyKidney DiseasesAdolescentAdultAgedBiopsyChinaFemaleHumansMaleMiddle AgedRetrospective StudiesYoung AdultCKDClinical indicationNorthwest ChinaPathological typeRenal biopsy

Identifiers

PMID41936014

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