ArticlePlant communications2026
A GPS2-like protein interacts with HOS15 and HDA6 to form a repressor complex that regulates ABA signaling and drought adaptation in Arabidopsis.
Article in Plant communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Plants rely on chromatin-mediated transcriptional control to fine-tune stress responses; however, the evolutionary conservation and functional diversification of repressor complexes remain incompletely understood. Here, we identify GPS2-like protein (GPL) as the missing component of the plant counterpart of the animal nuclear receptor-corepressor complex. GPL interacts with HOS15, PWR, and HDA6/HDA9 to form a chromatin repressor module that suppresses abscisic acid (ABA)-responsive genes. Loss-of-function gpl mutants exhibit ABA hypersensitivity and enhanced drought tolerance, whereas GPL overexpression confers ABA insensitivity. Mechanistically, GPL promotes histone H3K9 deacetylation and dimethylation at stress-responsive loci and stabilizes HOS15 to ensure its nuclear retention. Global RNA sequencing reveals widespread derepression of ABA-responsive transcriptional networks in gpl mutants. Under stress conditions, ABA destabilizes the GPL-HOS15 complex, relieving repression and activating defense-related genes. These findings establish GPL as the plant homolog of GPS2 and reveal that the GPL-HOS15 repressor complex functions as a chromatin-mediated rheostat to dynamically balance growth and drought adaptation. Our work provides mechanistic insight into stress-responsive chromatin remodeling and identifies GPL as a potential target for engineering climate-resilient crops.
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