Evidence map›Paper›PMID 41935949›Full record

ArticlePlant communications2026

PVA-based microneedle systems for precise molecular delivery in plants.

Mingzhuo Li, Aditi Dey Poonam, Deepjyoti Singh, Jin Xu, Hongwei Jing, Ziwei Zuo, Yipeng Huang, Nana Liu, Yajun Liu, Liping Gao and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plant communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mingzhuo LiDepartment of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695, USA.
Aditi Dey PoonamDepartment of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695, USA.
Deepjyoti SinghDepartment of Entomology and Plant Pathology, North Carolina State University, Raleigh, NC 27606, USA.
Jin XuDepartment of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695, USA.
Hongwei JingDepartment of Horticultural Science, North Carolina State University, Raleigh, NC 27606, USA.
Ziwei ZuoDepartment of Biological Sciences, School of Life Science, Anhui Agricultural University, No. 130, West Changjiang Road, Hefei, Anhui 230036, China.
Yipeng HuangState Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, No. 130, West Changjiang Road, Hefei, Anhui 230036, China.
Nana LiuState Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, No. 130, West Changjiang Road, Hefei, Anhui 230036, China.
Yajun LiuDepartment of Biological Sciences, School of Life Science, Anhui Agricultural University, No. 130, West Changjiang Road, Hefei, Anhui 230036, China.
Liping GaoDepartment of Biological Sciences, School of Life Science, Anhui Agricultural University, No. 130, West Changjiang Road, Hefei, Anhui 230036, China.
Tao XiaState Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, No. 130, West Changjiang Road, Hefei, Anhui 230036, China.
Anna E WhitfieldDepartment of Entomology and Plant Pathology, North Carolina State University, Raleigh, NC 27606, USA; Emerging Plant Disease and Global Food Security Cluster, North Carolina State University, Raleigh, NC 27695, USA.
Qingshan WeiDepartment of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695, USA; Emerging Plant Disease and Global Food Security Cluster, North Carolina State University, Raleigh, NC 27695, USA. Electronic address: qwei3@ncsu.edu.

Funding

Non-US Government Research Support type
6 · The paper itself

Abstract

Traditional crop delivery methods, such as foliar spray and soil application, face significant limitations, including nutrient loss, environmental impacts, and low delivery efficiency. Recent advances in nanomaterials have enabled novel molecular delivery platforms; however, challenges such as synthesis complexity, long-term stability, and compliance with rigorous biosafety regulations persist. To provide a simpler, lower-cost, and safer alternative, we developed a polyvinyl alcohol-based microneedle (MN) delivery system that can be precisely applied to various plant tissues, including stems, lateral branches, or petioles. This system demonstrates high delivery efficiency compared with conventional methods (3.5× higher tissue accumulation) while reducing the application dose (>90% reduction). It facilitates the delivery of diverse small molecules, ranging from fluorescent dyes to growth promoters and antiviral hormones, into plant tissues while causing minimal wounding stress. In particular, salicylic acid injection using MNs induced resistance to tomato spotted wilt virus in Nicotiana benthamiana, opening a new possibility for plant immunity engineering without gene editing. Overall, this easily fabricated and cost-effective MN system offers a promising tool for precision agriculture, enhancing plant health and productivity while significantly reducing the use of agrochemicals.

Indexed as

NicotianaPolyvinyl AlcoholMicroneedle Drug DeliveryNeedlesPolyvinyl Alcoholmicroneedlepathogen resistancephytohormoneplant deliveryprecision agriculture

Identifiers

PMID41935949
PMCPMC13370217

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.