Observational studyCurrent medical imaging2026
Utility of Diffusion-weighted Magnetic Resonance Imaging in Differentiating Connective Tissue Disease–associated Optic Neuritis from Idiopathic Optic Neuritis
Observational study in Current medical imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionTo evaluate the feasibility of using diffusion-weighted magnetic resonance imaging (DWI) to differentiate connective tissue disease-associated optic neuritis(CTD-ON) from idiopathic optic neuritis (IDON). MATERIALS AND
methodsand Methods: A retrospective observational study was conducted on 66 acute optic neuritis(ON) patients. Twenty-five patients (36 eyes) were comorbid with CTD, and 41 patients (49 eyes) had idiopathic ON and served as controls. All patients underwent routine magnetic resonance imaging (MRI) of the orbit and DWI. Affected optic nerves were evaluated for laterality, visual acuity, papilledema, visual outcome, and signal characteristics on DWI and conventional MRI. Clinical characteristics were compared using two-sample t-tests and chi-square tests. Spearman’s rank correlation, logistic regression, and receiver operating characteristic (ROC) curve analyses were performed to evaluate the diagnostic value of DWI for CTD-ON.
resultsCompared with the IDON group, patients with CTD-ON showed significantly more severe visual impairment and worse prognosis (P < 0.05). Optic nerve hyperintensity on DWI (DWI-H) was a significant risk factor for visual acuity at onset and final visual outcome in ON patients [ORs = 1.893 (95% CI: 1.322-2.711, P < 0.001), 1.716 (95% CI: 1.094-2.691, P = 0.019), respectively]. Acute CTD-ON patients were at higher risk of poor visual outcomes [OR = 2.593 (95% CI: 1.384-4.857, P = 0.003)]. ROC analysis showed that the combination of DWI-H and poor visual outcome yielded an AUC of 0.889 (95% CI: 0.820-0.959, P < 0.001), with a sensitivity of 88.9% and specificity of 77.6%. DISCUSSION: The pathogenesis of CTD-ON may involve the following mechanisms. First, CTD-related small-vessel vasculopathy, necrosis, and hypercoagulability-induced thrombosis may lead to vasculitic infarction and ischemic injury of the optic nerve, which manifests as hyperintensity on DWI. Second, autoantibodies induced by CTD may cross-react with neuronal cells.
conclusionPatients with CTD-ON demonstrate more severe visual impairment than those with IDON. The presence of DWI hyperintensity and poor prognosis in patients with ON should raise suspicion for CTD-ON in the appropriate clinical setting.
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