Evidence map›Paper›PMID 41935282›Full record

ReviewMalaria journal2026

Safety monitoring of the RTS,S/AS01

Adela Ashie, Martha Mandale, Anderson Ndalama, Delese Darko, Seth Seaneke, Eric K Boateng, George Sabblah, Abena Asamoa-Amoakohene, Kwame Amponsa-Achiano, Naziru T Mohammed and 10 more

Abstract readReview
In one paragraph

Review in Malaria journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Adela Ashie *Food and Drugs Authority, Accra, Ghana. adela.ashie@fda.gov.gh.
Martha Mandale *Pharmacy and Poisons Board, Nairobi, Kenya.
Anderson Ndalama *Pharmacy and Medicines Regulatory Authority, Lilongwe, Malawi.
Delese DarkoFood and Drugs Authority, Accra, Ghana.
Seth SeanekeFood and Drugs Authority, Accra, Ghana.
Eric K BoatengFood and Drugs Authority, Accra, Ghana.
George SabblahFood and Drugs Authority, Accra, Ghana.
Abena Asamoa-AmoakoheneFood and Drugs Authority, Accra, Ghana.
Kwame Amponsa-AchianoExpanded Programme on Immunization, Ghana Health Service, Accra, Ghana.
Naziru T MohammedExpanded Programme on Immunization, Ghana Health Service, Accra, Ghana.
Rose Jalang'oNational Vaccines and Immunization Programme, Nairobi, Kenya.
Edwin NkansahFood and Drugs Authority, Accra, Ghana.
Yvonne Adu-BoahenFood and Drugs Authority, Accra, Ghana.
Fred SiyoiPharmacy and Poisons Board, Nairobi, Kenya.
Anthony ToroitichPharmacy and Poisons Board, Nairobi, Kenya.
Christabel KhaembaPharmacy and Poisons Board, Nairobi, Kenya.
Pamela NambwaPharmacy and Poisons Board, Nairobi, Kenya.
Sujeet JainPharmacovigilance Unit, World Health Organization, Geneva, Switzerland.
Rafiq N A OkineGlobal Malaria Programme, World Health Organization, Geneva, Switzerland.
Alambo K MssusaVaccine Preventable Diseases Unit, World Health Organization Africa Regional Office, Brazzaville, Congo.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe pilot implementation of the RTSS/AS01 METHODS AND

resultsIn collaboration with technical partners, national health authorities monitored the safety of the RTS,S/AS01 CONCLUSIONS AND RECOMMENDATIONS: The pilot program highlighted PV challenges in resource-limited settings and provided useful insights for future vaccine rollouts. The lessons learned from these challenges emphasize the importance of sustained investment, particularly for AEFI investigations, and the need for innovations to improve health worker reporting. Research is needed to identify effective strategies for increasing reporting. Key recommendations include training and capacity building, resource allocation, surveillance and reporting, raising and maintaining public awareness, and collaboration and information sharing to ensure sustained PV efforts and robust safety surveillance in similar contexts.

Indexed as

Drug-Related Side Effects and Adverse ReactionsMalariaMalaria VaccinesPharmacovigilanceAdverse Drug Reaction Reporting SystemsGhanaHumansKenyaMalawiVaccines, SyntheticMalaria VaccinesRTS,S-AS01 vaccineVaccines, SyntheticAEFIAESIGhanaKenyaMalaria vaccineMalawiMVIPPharmacovigilanceRoutine PVRTS,SSafety

Identifiers

PMID41935282
PMCPMC13147739

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.