Evidence map›Paper›PMID 41935222›Full record

ArticleBone marrow transplantation2026

Impact of TP53 alterations on outcomes in pediatric and young adult patients with relapsed / refractory B-cell acute lymphoblastic leukemia after CD19-CAR T-Cell therapy.

Anna Alonso-Saladrigues, Elena Esperanza-Cebollada, Clara Vicente-Garcés, Sara Perez-Jaume, Nazaret Sánchez-Sierra, Mercè Richarte-Franqués, Albert Català, Alba Crespo-Carrasco, José-Luis Dapena, Esther Cuatrecasas Capdevila and 15 more

Abstract read
In one paragraph

Article in Bone marrow transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Anna Alonso-Saladrigues *CAR T-cell Unit. Leukemia and Lymphoma Department. Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu de Barcelona, Barcelona, Spain.ORCID 0000-0002-3195-5470
Elena Esperanza-Cebollada *Leukemia and Pediatric Hematology Disorders, Developmental Tumors Biology Group, Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Barcelona, Spain.
Clara Vicente-GarcésLeukemia and Pediatric Hematology Disorders, Developmental Tumors Biology Group, Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Barcelona, Spain.ORCID 0000-0002-2556-043X
Sara Perez-JaumeBiostatistics and Mathematics Research Unit, Sant Joan de Déu Pediatric Cancer Center Barcelona, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain.ORCID 0000-0002-9805-4810
Nazaret Sánchez-SierraCAR T-cell Unit. Leukemia and Lymphoma Department. Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu de Barcelona, Barcelona, Spain.
Mercè Richarte-FranquésLeukemia and Pediatric Hematology Disorders, Developmental Tumors Biology Group, Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Barcelona, Spain.
Albert CatalàCAR T-cell Unit. Leukemia and Lymphoma Department. Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu de Barcelona, Barcelona, Spain.
Alba Crespo-CarrascoLeukemia and Pediatric Hematology Disorders, Developmental Tumors Biology Group, Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Barcelona, Spain.ORCID 0009-0007-2608-6796
José-Luis DapenaCAR T-cell Unit. Leukemia and Lymphoma Department. Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu de Barcelona, Barcelona, Spain.
Esther Cuatrecasas CapdevilaCytogenetics Laboratory. Laboratory Diagnostic Service. Hospital Sant Joan de Déu de Barcelona, Esplugues de Llobregat, Barcelona, Spain.
Anna Faura MorrosCAR T-cell Unit. Leukemia and Lymphoma Department. Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu de Barcelona, Barcelona, Spain.
Maria A Ruiz-CoboCAR T-cell Unit. Leukemia and Lymphoma Department. Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu de Barcelona, Barcelona, Spain.
Laura ArquésCAR T-cell Unit. Leukemia and Lymphoma Department. Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu de Barcelona, Barcelona, Spain.
Nuria Conde CuevasCAR T-cell Unit. Leukemia and Lymphoma Department. Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu de Barcelona, Barcelona, Spain.
Sandra AndreuCytogenetics Laboratory. Laboratory Diagnostic Service. Hospital Sant Joan de Déu de Barcelona, Esplugues de Llobregat, Barcelona, Spain.
Ignacio IsolaHematology Laboratory, Hospital Sant Joan de Déu Barcelona, Esplugues de Llobregat, Barcelona, Spain.
Iolanda JordanPediatric Intensive Care Unit, Hospital Sant Joan de Déu de Barcelona, University of Barcelona, Esplugues de Llobregat, Barcelona, Spain.
Enric García-ReyApheresis Unit, Banc de Sang i Teixits, Barcelona, Spain.
Cristina LlanosClinical Research Unit, Fundació Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain.
Júlia MarsalStem Cell Transplant Unit. Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu de Barcelona, Barcelona, Spain.
Verónica CelisCAR T-cell Unit. Leukemia and Lymphoma Department. Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu de Barcelona, Barcelona, Spain.
Mireia CamósLeukemia and Pediatric Hematology Disorders, Developmental Tumors Biology Group, Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Barcelona, Spain.
Montserrat TorrebadellLeukemia and Pediatric Hematology Disorders, Developmental Tumors Biology Group, Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Barcelona, Spain.
Nerea Vega-GarcíaLeukemia and Pediatric Hematology Disorders, Developmental Tumors Biology Group, Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Barcelona, Spain. nerea.vega@sjd.es.
Susana RivesCAR T-cell Unit. Leukemia and Lymphoma Department. Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu de Barcelona, Barcelona, Spain. susana.rives@sjd.es.ORCID 0000-0002-5658-1831

Funding

Ministry of Economy and Competitiveness | Instituto de Salud Carlos III (Institute of Health Carlos III) PI21/00218Ministry of Economy and Competitiveness | Instituto de Salud Carlos III (Institute of Health Carlos III) RD24/0014/0006
6 · The paper itself

Abstract

Relapse remains the leading cause of treatment failure in pediatric and young adult patients with relapsed/refractory B-cell acute lymphoblastic leukemia (r/r B-ALL) undergoing chimeric antigen receptor T-cell (CAR-T) therapy. While prognostic factors for relapse have been identified, further refinement is needed. We conducted a single-center retrospective study of 69 patients treated with Tisagenlecleucel, to evaluate the prognostic impact of TP53 alterations (TP53

Indexed as

Antigens, CD19Immunotherapy, AdoptivePrecursor B-Cell Lymphoblastic Leukemia-LymphomaTumor Suppressor Protein p53AdolescentAdultChildChild, PreschoolFemaleHumansMalePrognosisReceptors, Antigen, T-CellRecurrenceRetrospective StudiesYoung AdultAntigens, CD19Receptors, Antigen, T-CellTP53 protein, humanTumor Suppressor Protein p53

Identifiers

PMID41935222
PMCPMC13241304

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.