Wdfy3-dependent autophagy impairment recapitulates presymptomatic neurodegenerative signatures in mice.

Aldo Vorkapich, Arshi Mustafa, Amanda L Flores-Torres, Konstantinos S Zarbalis, Cecilia Giulivi

Abstract read

In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aldo VorkapichDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, CA, 95616, USA.

Arshi Mustafa *Department of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA, 95817, USA.

Amanda L Flores-Torres *Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, CA, 95616, USA.

Konstantinos S Zarbalis *Department of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA, 95817, USA.

Cecilia Giulivi *Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, CA, 95616, USA. cgiulivi@ucdavis.edu.

Funding

Contributors to FXTAS ProgressionR21NS128751 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GIULIVI, CECILIA · 2022 to 2022

$439k

NIH HHS MH115347NIH HHS NS128751NINDS NIH HHS R21 NS128751

6 · The paper itself

Abstract

WDFY3/ALFY is an adaptor protein involved in selective autophagy. Loss of Wdfy3 in mice causes severe deficits in neuronal health, and pathogenic mutations in WDFY3 are associated with neurodevelopmental disorders in humans. As impaired autophagy is increasingly implicated in Parkinson's disease (PD) and other neurodegenerative disorders, we investigated whether Wdfy3 haploinsufficiency produces early molecular and cellular signatures of neurodegeneration in Wdfy3

Indexed as

Adaptor Proteins, Signal TransducingAutophagyNeurodegenerative DiseasesParkinson DiseaseAnimalsAutophagy-Related ProteinsBrainDisease Models, AnimalHumansMiceProteomicsSubstantia NigraAdaptor Proteins, Signal TransducingAutophagy-Related ProteinsWdfy3 protein, mouseAutophagyBiomarkersMitochondrial dysfunctionMouse modelNeurodegenerationParkinson’s diseaseProteomics

Identifiers

PMID41935068

DOI10.1038/s41598-026-43314-0

PMCPMC13201858

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.