ArticleNature communications2026
Experimental assessment of AI-based interactome mapping.
Abstract read
In one paragraph
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- An Atlas of Short Linear Motif-Mediated Human Protein-Protein Interactions.bioRxiv : the preprint server for biology · 2026Article
- Unveiling a missing component of the atypical type IV secretion system required for natural transformation of Helicobacter pylori.PLoS pathogens · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
45 authors.
Luke Lambourne *Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7001-7575
Anupama Yadav *Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Yang Wang *Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Alice Desbuleux *Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Dae-Kyum KimCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Florent LavalCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7744-6199
Kerstin Spirohn-FitzgeraldCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2071-1606
Tiziana CafarelliCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Carles PonsInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute for Science and Technology, Barcelona, Spain.
István A KovácsCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Noor JailkhaniCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Sadie SchlabachCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
David De RidderCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Katja LuckCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0003-2336-9225
Vladimir V BotchkarevCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Olivia DebnathCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Wenting BianCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Yun ShenCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Zhipeng YangCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Miles W MeeDonnelly Centre for Cellular and Biomolecular Research (CCBR), University of Toronto, Toronto, ON, Canada.
Mohamed HelmyDonnelly Centre for Cellular and Biomolecular Research (CCBR), University of Toronto, Toronto, ON, Canada.
Yves JacobCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Irma LemmensCenter for Medical Biotechnology, Vlaams Instituut voor Biotechnologie (VIB), Ghent, Belgium.
Thomas RollandCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6468-8391
Gregory G McClainCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Atina G CotéCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0340-9325
Marinella GebbiaCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Nishka KishoreCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Jennifer J KnappCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Joseph C MellorCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Gonen MemisogluDepartment of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-2901-3150
Jüri ReimandDepartment of Molecular Genetics, University of Toronto, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-2299-2309
Jan TavernierCenter for Medical Biotechnology, Vlaams Instituut voor Biotechnologie (VIB), Ghent, Belgium.
Michael E CusickCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Quan ZhongCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0003-2910-5597
Patrick AloyInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute for Science and Technology, Barcelona, Spain.ORCID http://orcid.org/0000-0002-3557-0236
Tong HaoCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7908-3256
Benoit CharloteauxCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0003-4282-9688
Frederick P RothCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Javier De Las RivasCancer Research Center (CiC-IBMCC, CSIC/USAL), Consejo Superior de Investigaciones Científicas (CSIC)/University of Salamanca (USAL), and Instituto de Investigacion Biomedica de Salamanca (IBSAL), Salamanca, Spain.ORCID http://orcid.org/0000-0002-0984-9946
Pascal Falter-BraunCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA. pascal.falter-braun@helmholtz-munich.de.ORCID http://orcid.org/0000-0003-2012-6746
David E HillCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA. david_hill@dfci.harvard.edu.ORCID http://orcid.org/0000-0001-5192-0921
Michael A CalderwoodCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA. michael_calderwood@dfci.harvard.edu.ORCID http://orcid.org/0000-0001-6475-1418
Jean-Claude TwizereCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA. jean-claude.twizere@uliege.be.ORCID http://orcid.org/0000-0002-8683-705X
Marc VidalCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA. marc_vidal@dfci.harvard.edu.
Funding
A S. cerevisiae high-coverage high-quality protein-protein binary interactome mapR01HG006061 · NHGRI · DANA-FARBER CANCER INST · PI CALDERWOOD, MICHAEL A, HILL, DAVID E. · 2011 to 2014
$3.1MInterface-resolution domain-domain interactome map of the yeast complexomeR01GM130885 · NIGMS · DANA-FARBER CANCER INST · PI VIDAL, MARC · 2019 to 2022
$2.7MIncomplete Penetrance via Edgetic SuppressionR01GM133185 · NIGMS · DANA-FARBER CANCER INST · PI CALDERWOOD, MICHAEL A, ROTH, FREDERICK P · 2019 to 2022
$2.4MNHGRI NIH HHS R01 HG006061U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI) R01GM130885U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI) R01GM133185
Abstract
Genotype-phenotype relationships are mediated through intricate networks of physical and functional interactions among macromolecules. Knowledge of the interactome is vital to understand and model genetics and cellular biology. Recent advances in accurately predicting tertiary protein structures using artificial intelligence (AI) approaches such as AlphaFold
Indexed as
Artificial IntelligenceProtein Interaction MappingProtein Interaction MapsSaccharomyces cerevisiae ProteinsHumansModels, MolecularProteomeSaccharomyces cerevisiaeProteomeSaccharomyces cerevisiae Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.