Evidence map›Paper›PMID 41935047›Full record

SynthesisThe pharmacogenomics journal2026

Economic effectiveness of pharmacogenomics-guided prescribing for psychiatric disorders: a systematic review and meta-analysis.

Ellen R Mason, Mohamed Y Ali, David S Gibson, Elaine K Murray, Richéal M Burns, Catriona Kelly

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in The pharmacogenomics journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ellen R MasonPersonalised Medicine Centre, School of Medicine, Ulster University, C-TRIC Builiding, Altanagelvin Hospital Campus, Glenshane Road, Derry∼Londonderry, BT47 6SB, UK.ORCID 0009-0004-0476-5518
Mohamed Y AliPersonalised Medicine Centre, School of Medicine, Ulster University, C-TRIC Builiding, Altanagelvin Hospital Campus, Glenshane Road, Derry∼Londonderry, BT47 6SB, UK.ORCID 0000-0002-2887-7627
David S GibsonPersonalised Medicine Centre, School of Medicine, Ulster University, C-TRIC Builiding, Altanagelvin Hospital Campus, Glenshane Road, Derry∼Londonderry, BT47 6SB, UK.
Elaine K MurrayPersonalised Medicine Centre, School of Medicine, Ulster University, C-TRIC Builiding, Altanagelvin Hospital Campus, Glenshane Road, Derry∼Londonderry, BT47 6SB, UK.
Richéal M BurnsDepartment of Health and Nutritional Science, Atlantic Technological University, Faculty of Science, Sligo, F91 YW50, Ireland.
Catriona KellyPersonalised Medicine Centre, School of Medicine, Ulster University, C-TRIC Builiding, Altanagelvin Hospital Campus, Glenshane Road, Derry∼Londonderry, BT47 6SB, UK. c.kelly@ulster.ac.uk.ORCID 0000-0003-3740-4511

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pharmacogenomics (PGx)-guided prescribing is a promising approach to reduce variability in drug response, although its cost-effectiveness remains uncertain. We performed a systematic review and meta-analysis evaluating the cost-effectiveness of PGx-guided prescribing compared to standard care in psychiatry. In January 2026, we searched MEDLINE, Embase and PsycINFO for studies published between 2014 and 2025. We included any peer-reviewed study that included adults with a diagnosed psychiatric disorder, comparing PGx-guided prescribing to standard care, and reported both quality-of-life and economic outcomes. Given the lack of consensus on synthesising economic evidence, both a narrative synthesis and meta-analysis were conducted. Pooled incremental net benefit (INB) was used as the effect measure for the meta-analysis and heterogeneity measures including the I

Indexed as

Mental DisordersPharmacogeneticsCost-Benefit AnalysisCost-Effectiveness AnalysisDrug PrescriptionsHumansQuality of Life

Identifiers

PMID41935047
PMCPMC13050323

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.