Evidence map›Paper›PMID 41935019›Full record

ArticleThe Journal of physiology2026

Ro5-4864, a ligand of the mitochondrial translocator protein, protects against heart failure in mice via regulation of the p62-Keap1-Nrf2 axis.

Daphne A Diloretto, Phung N Thai, Gabriela Grigorean, Veneese J Brown, Tjien Dwyer, Nipavan Chiamvimonvat, Elena N Dedkova, Saul Schaefer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Daphne A DilorettoDepartment of Internal Medicine, University of California, Davis, California, USA.
Phung N ThaiDepartment of Internal Medicine, University of California, Davis, California, USA.
Gabriela GrigoreanProteomics Core, University of California, Davis, California, USA.
Veneese J BrownCenter for Health and the Environment, University of California, Davis, California, USA.
Tjien DwyerDepartment of Internal Medicine, University of California, Davis, California, USA.
Nipavan ChiamvimonvatDepartment of Internal Medicine, University of California, Davis, California, USA.
Elena N DedkovaDepartment of Molecular Biosciences, University of California, Davis, California, USA.ORCID https://orcid.org/0000-0002-0601-9816
Saul SchaeferDepartment of Internal Medicine, University of California, Davis, California, USA.ORCID https://orcid.org/0000-0001-7689-8134

Funding

Translational Study of Cardiac DysfunctionR01HL085727 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHIAMVIMONVAT, NIPAVAN, SIRISH, PADMINI · 2008 to 2022
$5.7M
Fumarate drugs rescue cardiac dysfunction in mouse models of Friedreich's ataxiaR01HL155907 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DEDKOVA, ELENA N. · 2021 to 2024
$1.8M
Mechanisms Underpinning Afterload-Induced Atrial FibrillationF31HL168956 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DILORETTO, DAPHNE AGOSTINA · 2023 to 2024
$81k
American Heart Association 19TPA34910148American Heart Association 24CDA1276831American Heart Association 25TPA1478903NHLBI NIH HHS F31 HL168956NHLBI NIH HHS R01 HL085727NHLBI NIH HHS R01 HL155907NIH HHS F31HL168956NIH HHS R01HL085727NIH HHS R01HL155907
6 · The paper itself

Abstract

The 18-kDa mitochondrial translocator protein (TSPO) has been shown to modulate mitochondrial function and the cardiac response to pressure overload. We have previously shown that conditional knockout of TSPO limited the development of heart failure in the murine model of transverse aortic constriction (TAC). In this study, we hypothesized that similar protection could be achieved by a ligand of TSPO, Ro5-4864 (Ro5), in an in-vivo model of pressure-overload induced heart failure. To test this hypothesis, C57/BL6J mice had TAC or sham surgery, with daily 0.1 mg/kg Ro5 or saline intra-peritoneal injection for 8 weeks, with echocardiographic measurement of left ventricular (LV) size and function. Cardiac tissue protein expression was then analyzed by LC/MS. Markers of inflammation were quantified via western blot. Isolated murine cardiomyocytes were co-treated with 25 µM H

Indexed as

BenzodiazepinonesCardiotonic AgentsHeart FailureKelch-Like ECH-Associated Protein 1NF-E2-Related Factor 2Receptors, GABASequestosome-1 ProteinAnimalsMaleMiceMice, Inbred C57BLMyocytes, CardiacOxidative StressSignal Transduction4'-chlorodiazepamBenzodiazepinonesBzrp protein, mouseCardiotonic AgentsKeap1 protein, mouseKelch-Like ECH-Associated Protein 1Nfe2l2 protein, mouseNF-E2-Related Factor 2Receptors, GABASequestosome-1 ProteinSqstm1 protein, mouseheart failurep62‐Keap1‐Nrf2Ro5‐4864TSPO

Identifiers

PMID41935019
PMCPMC13481017

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.