Evidence map›Paper›PMID 41934873›Full record

ArticleThe journal of nutrition, health & aging2026

Accelerated biological aging and brain structural alterations linking air pollution to dementia risk: a prospective cohort study.

Ruoyao Huang, Yacong Bo, Jing Guo, Yang Liu, Chunlei Li, Jintao Han, Shuo Lu, Xiangying Suo

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Article in The journal of nutrition, health & aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Ruoyao HuangOffice of Hospital Administration, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China; National Engineering Laboratory for Internet Medical Systems and Applications, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Yacong BoSchool of Public Health, Zhengzhou University, Zhengzhou 450001, China; NHC Key Laboratory of Birth Defects Prevention, Henan Key Laboratory of Population Defects Prevention, Zhengzhou 450002, China.
Jing GuoSchool of Physical Education (Main Campus), Zhengzhou University, Zhengzhou 450001, China.
Yang LiuSchool of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Chunlei LiSchool of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Jintao HanSchool of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Shuo LuSchool of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Xiangying SuoSchool of Public Health, Zhengzhou University, Zhengzhou 450001, China. Electronic address: xy_suo123@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo examine the association of air pollution with dementia and brain structural alternations, and further to explore the mediating role of accelerated biological aging and brain atrophy in the air pollution-dementia association.

designA prospective cohort study. SETTING AND

participantsA total of 488,348 UK Biobank participants without dementia were included at baseline. EXPOSURE: Air pollution, including PM MEASUREMENTS: Cox proportional hazards regression models were used to evaluate the association between air pollution and incident dementia, while linear regression models were used to assess its associations with global and 80 regional brain structures. The mediating roles of biological aging acceleration (measured by Klemera-Doubal method Biological Age [KDM-BA] and PhenoAge) and brain structures in the air pollution-dementia association were evaluated using structural equation modeling (SEM).

resultsCompared to participants with the lowest tertile of air pollution exposure, those in the highest exposure group had higher risks of dementia (HR [95%CI]: 1.14 [1.08, 1.21] for PM

conclusionsOur findings support the association between air pollution and dementia, as well as a reduction in global and several regional brain volumes. Notably, biological age acceleration and brain atrophy mediated the air pollution-dementia association.

Indexed as

AgingAir PollutionBrainDementiaEnvironmental ExposureAgedAir PollutantsAtrophyFemaleHumansMaleMiddle AgedParticulate MatterProportional Hazards ModelsProspective StudiesRisk FactorsAir PollutantsParticulate MatterAir pollutionBiological agingBrain structureDementia

Identifiers

PMID41934873
PMCPMC13087587

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.