Evidence map›Paper›PMID 41934658›Full record

ArticleInflammatory bowel diseases2026

Efficacy and safety of ulcerative colitis therapies do not differ by age: A post hoc analysis of randomized controlled trials.

Emily C L Wong, John K Marshall, Christopher Ma, Vipul Jairath, Walter Reinisch, Neeraj Narula

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Article in Inflammatory bowel diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Emily C L WongDivision of Gastroenterology, Department of Medicine and Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada.ORCID 0000-0001-9472-201X
John K MarshallDivision of Gastroenterology, Department of Medicine and Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada.
Christopher MaDivision of Gastroenterology, Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, ON, Canada.ORCID 0000-0002-4698-9948
Vipul JairathDivision of Gastroenterology, Department of Medicine, Western University, London, ON, Canada.
Walter ReinischDivision of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-2088-091X
Neeraj NarulaDivision of Gastroenterology, Department of Medicine and Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada.ORCID 0000-0002-1536-8436

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOlder adults with ulcerative colitis (UC) are often undertreated with advanced therapies due to safety concerns. We evaluated whether outcomes differ by age in randomized trials.

methodsPost hoc analysis of 2841 participants from 13 UC induction trials of biologics and JAK inhibitors compared efficacy (patient-reported outcomes 2 response/remission, clinical remission, endoscopic improvement) and safety between patients ≥60 years of age vs <60 years of age.

resultsEfficacy and safety outcomes were similar across age groups, with minor therapy-specific variation. Hospitalization was numerically higher in older adults.

conclusionsAdvanced therapies show comparable efficacy and safety in UC regardless of age.

Indexed as

Biological ProductsColitis, UlcerativeJanus Kinase InhibitorsAdultAgedAge FactorsFemaleHumansMaleMiddle AgedRandomized Controlled Trials as TopicRemission InductionTreatment OutcomeBiological ProductsJanus Kinase Inhibitorsclinical remissioninflammatory bowel diseasePRO-2 remissionPRO-2 responseulcerative colitis

Identifiers

PMID41934658
PMCPMC13414529

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.