ArticleJournal of molecular histology2026
Effects of Centella asiatica extract on burn wound healing in streptozotocin-induced diabetic rats: a pathological and molecular evaluation.
Article in Journal of molecular histology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Centella Asiatica Alleviates Type 2 Diabetes-Related Hepatic Glycolipid Disorders via Regulating UPP1-Mediated Pyrimidine Metabolism.Current issues in molecular biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
This study investigated the pathological and molecular effects of Centella asiatica extract-based cream and ointment formulations on burn wound healing in streptozotocin-induced diabetic rats. A total of 92 female Wistar albino rats were assigned to six groups: control (C), burn (B), diabetes (D), diabetes + burn (DB), diabetes + burn + cream (DBC), and diabetes + burn + ointment (DBP). Each group was further subdivided into 7-day (First subgroups) and 14-day (Second subgroups) treatment subgroups. Diabetes was induced by a single intraperitoneal injection of streptozotocin (55 mg/kg). Second-degree thermal burns (1 cm diameter) were induced on the dorsal skin of rats in the burn groups (B, DB, DBC, and DBP). Following burn induction, the DBC and DBP groups received daily topical treatment with a 2.5% Centella asiatica extract-based cream or ointment, respectively. Necropsies were performed on day 7 in the first subgroups and on day 14 in the second subgroups following burn model induction. Wound healing was evaluated macroscopically and histopathologically, and gene expression levels of TNF-α, FGF-2, EGF, VEGF, and IGF-1 were analyzed using quantitative real-time PCR. Wound areas were significantly larger in the DB group, whereas significant reductions were observed on days 7 and 14 in the treated groups (p < 0.05). Histopathological analysis revealed decreased inflammatory cell infiltration and enhanced fibroblast/fibrocyte density, angiogenesis, and epithelialization in the treated groups. Molecular analyses demonstrated significantly decreased TNF-α and increased FGF-2, EGF, VEGF, and IGF-1 expression in the treated groups compared to the DB group (p < 0.05). In conclusion, treatment with Centella asiatica extract supported healing in a diabetic burn model through anti-inflammatory, regenerative, angiogenic, and epithelializing effects. Notably, molecular analyses demonstrated a previously unreported increase in local IGF-1 levels following Centella asiatica extract treatment, supported by pathological findings.
Indexed as
Identifiers
41934524What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.