ArticleJournal of anesthesia2026
Comparative interrupted time series analysis of Nociception Level index during tracheal intubation and pneumoperitoneum in robot-assisted laparoscopic radical prostatectomy: a sub-analysis of the NOLDOR study.
Article in Journal of anesthesia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
Funding
Abstract
This prespecified secondary analysis of a randomized controlled trial investigated event-related dynamics of the Nociception Level (NOL) index during tracheal intubation and initiation of pneumoperitoneum in patients undergoing robot-assisted laparoscopic radical prostatectomy. Continuous NOL values recorded every 5 s were analyzed within 5-min windows before and after each event using segmented regression models within a comparative interrupted time series (ITS) framework incorporating a contemporaneous control group. Forty-nine patients were included (NOL-guided, n = 25; control, n = 24). At intubation, the NOL-guided group showed a lower pre-event baseline (12.2 vs 19.2; group difference - 6.97, p = 0.003) and a reduced post-event peak (32.9 vs 44.1; - 11.2, p = 0.034), whereas immediate level changes did not differ (p = 0.82). Similar findings were observed at pneumoperitoneum, with lower baseline (8.09 vs 12.0; - 3.93, p = 0.024) and peak NOL values (12.9 vs 23.6; - 10.8, p = 0.013) but no difference in immediate level change (p = 0.47). By integrating a prespecified secondary analysis within a comparative ITS framework, this study offers a time-resolved perspective on intraoperative NOL dynamics beyond conventional event-based analyses.
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