Evidence map›Paper›PMID 41934468›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2026

Evidence for a role of calcium and vitamin D in the regulation of manganese homeostasis and in the prevention or management of manganese-induced disease.

Hope Lee, Sarah Marie Gerges, Simran Gill, Amro Tambal, Harneet Kaur Bahia, Mohamed Aburadi, Shivani Grover, Somshuvra Mukhopadhyay, Cathleen L Doherty, Sean Stratton and 1 more

Abstract read
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hope LeeDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers-New Jersey Medical School, Newark, New Jersey, United States.
Sarah Marie GergesDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers-New Jersey Medical School, Newark, New Jersey, United States.
Simran GillDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers-New Jersey Medical School, Newark, New Jersey, United States.ORCID 0009-0004-6376-8815
Amro TambalDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers-New Jersey Medical School, Newark, New Jersey, United States.
Harneet Kaur BahiaDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers-New Jersey Medical School, Newark, New Jersey, United States.ORCID 0009-0001-7603-6400
Mohamed AburadiDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers-New Jersey Medical School, Newark, New Jersey, United States.ORCID 0009-0007-9094-1603
Shivani GroverDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers-New Jersey Medical School, Newark, New Jersey, United States.ORCID 0000-0003-0499-3786
Somshuvra MukhopadhyayDivision of Pharmacology and Toxicology, College of Pharmacy and Institute for Neuroscience, University of Texas at Austin, Austin, Texas, United States.ORCID 0000-0002-3420-7830
Cathleen L DohertyEnvironmental and Health Science Institute, Rutgers University, Piscataway, New Jersey, United States.ORCID 0000-0001-8831-6330
Sean StrattonEnvironmental and Health Science Institute, Rutgers University, Piscataway, New Jersey, United States.ORCID 0000-0002-1311-3069
Sylvia ChristakosDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers-New Jersey Medical School, Newark, New Jersey, United States.ORCID 0000-0001-9148-5549

Funding

Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI BRIAN T BUCKLEY · 1988 to 2026
$47.4M
Nutrigenomics of Intestinal Vitamin D ActionR01DK112365 · NIDDK · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI SYLVIA S CHRISTAKOS, James C. Fleet · 2017 to 2026
$4.2M
Role and mechanisms of excretion in manganese neurotoxicityR01ES031574 · NIEHS · UNIVERSITY OF TEXAS AT AUSTIN · PI MUKHOPADHYAY, SOMSHUVRA · 2020 to 2025
$3.5M
Creating Pb Risk Mitigation Using Source Apportionment in an EJ CommunityF31ES035633 · NIEHS · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI STRATTON, SEAN · 2023 to 2025
$112k
HHS | National Institutes of Health (NIH) DK112365HHS | National Institutes of Health (NIH) ES00502HHS | National Institutes of Health (NIH) ES031574NIDDK NIH HHS R01 DK112365NIEHS NIH HHS F31 ES035633NIEHS NIH HHS P30 ES005022NIEHS NIH HHS R01 ES031574
6 · The paper itself

Abstract

SLC30A10 mediates manganese (Mn) efflux in both the intestine and liver, protecting against Mn toxicity. In previous studies, we found that

Indexed as

CalciumCalcium, DietaryHomeostasisManganeseVitamin DAnimalsCalcitriolCalcium ChannelsCation Transport ProteinsFemaleIntestinal MucosaLiverMaleMiceMice, Inbred C57BLMice, KnockoutCalcitriolCalciumCalcium ChannelsCalcium, DietaryCation Transport ProteinsManganeseTrpv6 protein, mouseTRPV Cation ChannelsVitamin Dcalciummanganesevitamin D

Identifiers

PMID41934468
PMCPMC13127827

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.