Evidence map›Paper›PMID 41934344›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026

Lymphocyte Antigen 6G Mediates Vagotomy-Associated Reduction in Body Weight.

Ting Liu, April S Caravaca, Min Cai, Wanmin Dai, Jérômine Jeanne Vacquié, Qi Guo, Peter Holicek, Maxime Villet, Patricia Teixeira Mendes, Yuyang Zhang and 9 more

Abstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Ting LiuLaboratory of Immunobiology, Center for Bioelectronic Medicine, Division of Cardiovascular Medicine, Department of Medicine, Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
April S CaravacaLaboratory of Immunobiology, Center for Bioelectronic Medicine, Division of Cardiovascular Medicine, Department of Medicine, Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Min CaiDivision of Cardiovascular Medicine, Department of Medicine, Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Wanmin DaiLaboratory of Immunobiology, Center for Bioelectronic Medicine, Division of Cardiovascular Medicine, Department of Medicine, Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Jérômine Jeanne VacquiéLaboratory of Immunobiology, Center for Bioelectronic Medicine, Division of Cardiovascular Medicine, Department of Medicine, Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Qi GuoLaboratory of Immunobiology, Center for Bioelectronic Medicine, Division of Cardiovascular Medicine, Department of Medicine, Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Peter HolicekLaboratory of Immunobiology, Center for Bioelectronic Medicine, Division of Cardiovascular Medicine, Department of Medicine, Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Maxime VilletLaboratory of Immunobiology, Center for Bioelectronic Medicine, Division of Cardiovascular Medicine, Department of Medicine, Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Patricia Teixeira MendesLaboratory of Immunobiology, Center for Bioelectronic Medicine, Division of Cardiovascular Medicine, Department of Medicine, Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Yuyang ZhangLaboratory of Immunobiology, Center for Bioelectronic Medicine, Division of Cardiovascular Medicine, Department of Medicine, Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Rubén R SimónLaboratory of Immunobiology, Center for Bioelectronic Medicine, Division of Cardiovascular Medicine, Department of Medicine, Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Shengduo PeiDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solna, Sweden.
Fredrik WermelingDivision of Rheumatology, Department of Medicine, Solna, Karolinska Institutet, and Karolinska University Hospital Solna, and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Stephen G MalinDivision of Cardiovascular Medicine, Department of Medicine, Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Mikael C I KarlssonDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solna, Sweden.
Vladimir S ShavvaLaboratory of Immunobiology, Center for Bioelectronic Medicine, Division of Cardiovascular Medicine, Department of Medicine, Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Carolina E HagbergDivision of Cardiovascular Medicine, Department of Medicine, Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-5497-2855
Laura TarnawskiLaboratory of Immunobiology, Center for Bioelectronic Medicine, Division of Cardiovascular Medicine, Department of Medicine, Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID https://orcid.org/0000-0001-7993-0232
Peder S OlofssonLaboratory of Immunobiology, Center for Bioelectronic Medicine, Division of Cardiovascular Medicine, Department of Medicine, Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID https://orcid.org/0000-0003-3473-5948

Funding

China Scholarship Council (CSC) 202206380036Hjärt- Lungfonden (Swedish Heart- Lung Foundation) 20200827Hjärt- Lungfonden (Swedish Heart- Lung Foundation) 20210524Hjärt- Lungfonden (Swedish Heart- Lung Foundation) 20230006Karolinska Institutet (KI) 2022-0170Karolinska Institutet (KI) 2023-01461Karolinska Institutet (KI) FoUI-987284MedTechLabs 954544Novo Nordisk Foundation Center for Basic Metabolic Research (NovoNordisk Foundation Center for Basic Metabolic Research) 0092494Vetenskapsrådet (VR) 2020-04443Vetenskapsrådet (VR) 2024-02432Vetenskapsrådet (VR) 2024-03735
6 · The paper itself

Abstract

Dysregulation of adipocyte function is an important component of metabolic and cardiovascular diseases. It is increasingly evident that interorgan neuroimmune crosstalk in adipose tissue maintains adipose tissue functionality, yet the molecular mechanisms are incompletely understood. The vagus nerve regulates numerous physiological functions, including inflammation and weight control, even in tissues lacking direct cholinergic innervation. In this study, we examined whether vagal signaling is involved in maintaining baseline homeostasis in epididymal white adipose tissue (eWAT) by investigating how disrupting vagus signaling affects adipose tissue physiology. As expected, vagotomized male animals had lower body weight and epididymal white adipose tissue mass as compared with controls. Vagotomized animals showed increased Ly6G

Indexed as

Adipose Tissue, WhiteAntigens, LyBody WeightVagotomyVagus NerveWeight LossAnimalsHomeostasisMaleMiceMice, Inbred C57BLMice, KnockoutNeutrophilsSignal TransductionAntigens, LyLy6G antigen, mouseLy6Gneutrophilsvagotomyweight loss

Identifiers

PMID41934344
PMCPMC13050019

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.