Evidence map›Paper›PMID 41934337›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026

Testosterone Exposure During Fetal Masculinization Programming Window Determines the Kidney Size in Adult Mice.

Arttu Junnila, Kalle T Rytkönen, Guillermo Martinez-Nieto, Mats Perk, Otto Mäkelä, Hao Li, Jenni Airaksinen, Ida Hyötyläinen, Oliver Mehtovuori, Asta Laiho and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Arttu JunnilaInstitute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland.ORCID https://orcid.org/0000-0002-1134-0962
Kalle T RytkönenInstitute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland.
Guillermo Martinez-NietoInstitute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland.
Mats PerkTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.
Otto MäkeläStem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Hao LiStem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Jenni AiraksinenInstitute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland.
Ida HyötyläinenInstitute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland.
Oliver MehtovuoriInstitute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland.
Asta LaihoTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.
Claes OhlssonDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, the Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.
Laura L EloInstitute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland.
Satu KuureStem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0002-9076-0622
Matti PoutanenInstitute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland.
Petra SipiläInstitute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland.ORCID https://orcid.org/0000-0001-8187-7143

Funding

Institute of Biomedicine, University of TurkuJalmari ja Rauha Ahokkaan Säätiö (Jalmari and Rauha Ahokas Foundation)Organon RD FinlandSigrid Juséliuksen Säätiö (Sigrid Jusélius Stiftelse)Turun Yliopistosäätiö (Turku University Foundation)
6 · The paper itself

Abstract

Kidney size is sex-dimorphic and regulated by androgens in adult humans and mice. However, the effects of developmental androgen deficiency on kidneys remain elusive. We hypothesized that androgens program future kidney growth during fetal development. Male mice lacking the main testosterone-producing enzyme HSD17B3 had reduced testosterone at embryonic day 15.5, but the concentrations increased by E18.5, creating a short time window of androgen deficiency resulting in reduced kidney size in adult males. In male Hsd17b3

Indexed as

Fetal DevelopmentKidneyTestosteroneAndrogensAnimalsFemaleMaleMiceMice, Inbred C57BLMice, KnockoutOrgan SizePregnancyReceptors, AndrogenSignal TransductionAndrogensReceptors, AndrogenTestosteroneARHNF4AIGFBP5kidney growthmasculinization programming windowtestosterone

Identifiers

PMID41934337
PMCPMC13050020

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.