Evidence map›Paper›PMID 41934330›Full record

ReviewThe Journal of infectious diseases2026

Evidence-Based Assessment of the Role of Pharyngeal Gonorrhea and Commensal Neisseria Species in the Emergence of Antimicrobial Resistance in Neisseria Gonorrhoeae: Data Gaps and Future Research.

Amber D Kimble, Yukari C Manabe, Johan H Melendez

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Amber D KimbleDivision of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-6785-1596
Yukari C ManabeDivision of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-8619-5598
Johan H MelendezDivision of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-6586-051X

Funding

TrainingU54EB007958 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI Yukari C Manabe · 2007 to 2026
$34.6M
Characterizing Antimicrobial Resistance in Pharyngeal Neisseria gonorrhoeae Infections and the Role of Commensal Neisseria SpeciesK01AI153546 · NIAID · JOHNS HOPKINS UNIVERSITY · PI MELENDEZ, JOHAN HUMBERTO · 2020 to 2024
$651k
CDC HHSNIAID NIH HHS K01 AI153546NIBIB NIH HHS U54 EB007958NIH HHS K01AI153546NIH HHS U54EB007958U.S. Department of Health and Human Services NU50CD300866
6 · The paper itself

Abstract

Antimicrobial resistance in Neisseria gonorrhoeae (NG) represents a global public health threat. NG has progressively developed resistance to current and previously recommended antibiotics, including the currently recommended treatment, ceftriaxone. Pharyngeal NG infections can contribute to the sustained transmission of gonorrhea as pharyngeal infections are often asymptomatic, can persists, and remain undiagnosed. Pharyngeal NG infections play a major role in the emergence of antimicrobial resistance in NG as horizontal gene transfer of resistance markers is common between NG and commensal Neisseria species which colonize the oropharynx. We review the evidence on the contribution of pharyngeal NG infections and commensal Neisseria species to the emergence of antimicrobial resistance in NG, outline research gaps, and propose potential research topics. Improved understanding of pharyngeal NG pathogenesis and how NG acquires antimicrobial resistance markers through horizontal gene transfer from commensal Neisseria species is critical to curtail the rapid evolution of antimicrobial resistance in NG and preserve the clinical utility of currently available and future antimicrobials.

Indexed as

Anti-Bacterial AgentsDrug Resistance, BacterialGonorrheaNeisseriaNeisseria gonorrhoeaePharyngeal DiseasesGene Transfer, HorizontalHumansPharynxAnti-Bacterial Agentsantimicrobial resistancecommensal Neisseria specieshorizontal gene transferNeisseria gonorrhoeaepharyngeal Neisseria gonorrhoeae

Identifiers

PMID41934330
PMCPMC13169378

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.