ArticleCannabis and cannabinoid research2026
Assessments of Evoked and Spontaneous Pain Following Administration of Gabapentin and the Cannabinoid CB
Article in Cannabis and cannabinoid research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionCannabinoid CB MATERIALS AND
methodsWe compared the impact of LY2828360 on evoked and spontaneous pain in a spared nerve injury (SNI) model using a within-subjects design in rats. First, we used an unbiased CPP approach to verify that an analgesic dose of gabapentin (GBP) (100 mg/kg, i.p.) produces CPP in rats with SNI, but not in sham-operated rats (Experiment 1). We then used a within-subjects design to ascertain whether LY2828360 (10 mg/kg i.p., chronic) would suppress both evoked and spontaneous pain in rats with SNI (Experiment 2). To assess spontaneous/affective pain behavior, we tested the ability of chronic dosing with LY2828360, in comparison to vehicle, to prevent GBP-induced CPP in the SNI model, as failure to develop CPP to GBP following treatment with an analgesic has been considered evidence of suppression of spontaneous pain. To assess evoked pain behavior, paw withdrawal thresholds were measured in the same rats used for CPP.
resultsGBP produced CPP in rats with SNI, but not sham surgery, and suppressed SNI-induced mechanical hypersensitivity in Experiment 1. In Experiment 2, LY2828360 reliably suppressed mechanical hypersensitivity in the paw
conclusionThese studies document that CB
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