ArticleThe International journal of artificial organs2026
Removal of activated neutrophils by a polymyxin B-immobilized fiber (PMX) column.
Article in The International journal of artificial organs, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPolymyxin B-immobilized fiber (PMX) columns are used to treat endotoxemic septic shock and have also been considered for the acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF), a condition defined by the absence of infection. Since the potential therapeutic effects beyond endotoxin adsorption remain unclear, we investigated the in vitro adsorption of various leukocyte subtypes using PMX columns under controlled stimulation.
methodsWhole blood from six healthy donors was treated with or without llipopolysaccharide (LPS) to model leukocyte activation. Leukocyte subsets and activation (CD11b
resultsThe removal capacities of monocytes, granulocytes, and neutrophils were significantly higher with PMX column hemoperfusion than with the control column, with more pronounced effects after LPS stimulation. Lymphocyte removal was not significant. Activated CD11b
conclusionsPMX columns preferentially removed activated granulocytes/neutrophils and reduced NLR in vitro. These findings provide hypothesis-generating mechanistic insights into how PMX may modulate activated leukocyte profiles beyond endotoxin adsorption.
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