ArticleBritish journal of clinical pharmacology2026
Effect of oxycodone vs. morphine as first-line opioid on new persistent opioid use after orthopaedic surgery: A prospective sequential cohort study.
Article in British journal of clinical pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Effect of oxycodone vs. morphine as first-line opioid on new persistent opioid use after orthopaedic surgery: A prospective sequential cohort study.British journal of clinical pharmacology · 2026Article
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6 authors.
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Abstract
backgroundPostoperative opioids, intended for short-term analgesia, contribute to new persistent opioid use in 1%-7% of patients, adversely affecting outcomes. Oxycodone may carry higher risk than morphine, though long-term data are limited. This prospective comparative sequential cohort study assessed whether replacing from oxycodone with morphine as first-line opioid after orthopaedic surgery affected new persistent opioid use at 6 months and maintained analgesic equivalence.
methodsPatients ≥18 years undergoing orthopaedic surgery requiring ≥1 night hospitalization were enrolled April 2023 to January 2024. PRIMARY OUTCOME: new persistent opioid use at 6 months, assessed by online survey. SECONDARY OUTCOME: analgesic effectiveness assessed by pain at rest (NRS ≥ 4) at discharge and 6 months, and daily opioid use (oral morphine equivalents) during hospitalization.
resultsOf 3675 eligible patients, 1894 (51.5%) completed the survey and were included (mean [SD] age 62.9 [13.1] year; 62.5% female). Among these, 1021 were in the morphine first-line opioid cohort and 873 in the oxycodone first-line opioid cohort. The proportion of new persistent opioid use at 6 months after surgery was 2.5% (morphine) vs. 2.6% (oxycodone) (p = .90). Pain at rest (NRS ≥ 4) was reported by 9.9% vs. 12.5% at discharge, and 19.3% vs. 19.7% at 6 months (morphine vs. oxycodone). Median (IQR) daily opioid dose during hospitalization was 12.3 (0-30) and 15 mg (0-30) (morphine vs. oxycodone). No significant differences were observed.
conclusionsReplacing oxycodone with morphine as first-line opioid after orthopaedic surgery did not appear to reduce new persistent opioid use (NPOU) and provided comparable analgesia.
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