ReviewChemistry (Weinheim an der Bergstrasse, Germany)2026
Self-Immolative Gels: Programmable Degradation Using Self-Immolative Linkers and Polymers.
Review in Chemistry (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
2 authors.
Funding
Abstract
Gels have diverse structures and properties, making them of interest for a broad range of applications from pollution control to regenerative medicine. The controlled and stimulus-triggered breakdown or property modulation of gels can lead to specific functions, such as sensing or drug release. Self-immolative linkers (SILs) and self-immolative polymers (SIPs) benefit from reaction cascades that allow a single stimulus-mediated bond cleavage event to be translated across multiple bonds or even along an entire polymer chain. In this Concept article, we begin by introducing the chemistry fundamentals behind SILs and SIPs. Then, the incorporation of SILs into gel systems through cargo modification and their use in cross-linkers is presented. We then discuss SIP organogels and how SIP systems have been imparted with the hydrophilic components needed to achieve hydrogels. A focus is given to the chemistry involved, and how this chemistry can be harnessed for potential applications. Finally, we present a summary and outlook for the field, examining the current status, and directions for future work.
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Registered trials
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