Evidence map›Paper›PMID 41934110›Full record

ArticleInterdisciplinary cardiovascular and thoracic surgery2026

Clamp On vs Off Impact of Distal Anastomotic Technique During Ascending Aortic Replacement in Acute Type A Aortic Dissection: IRAD Insights.

Stevan S Pupovac, Omar A Jarral, Santi Trimarchi, Ibrahim Sultan, Bradley Leshnower, Nimesh D Desai, Thoralf M Sundt, Puja Kachroo, Qing-Guo Li, Chih-Wen Pai and 4 more

Abstract readComparative Study
In one paragraph

Article in Interdisciplinary cardiovascular and thoracic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Extent of Acute Type A Aortic Dissection in Patients With Organ Cysts.Interdisciplinary cardiovascular and thoracic surgery · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Stevan S PupovacDepartment of Cardiovascular & Thoracic Surgery, Northwell Health, Manhasset, NY, 11103, USA.ORCID 0000-0001-5477-6136
Omar A JarralDepartment of Cardiovascular & Thoracic Surgery, Northwell Health, Manhasset, NY, 11103, USA.
Santi TrimarchiDepartment of Scienze Cliniche e di Comunita/Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, 20122, Italy.ORCID 0000-0001-5996-3264
Ibrahim SultanDepartment of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA, 15213, USA.ORCID 0000-0002-1737-4012
Bradley LeshnowerDivision of Cardiothoracic Surgery, Emory University, Atlanta, GA, 30322, USA.
Nimesh D DesaiDepartment of Cardiovascular Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA.ORCID 0000-0002-4456-5674
Thoralf M SundtDepartment of Surgery, Massachusetts General Hospital, Boston, MA, 02114, USA.
Puja KachrooCardiovascular Surgery, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Qing-Guo LiDepartment of Cardiovascular Surgery, Nanjing Medical University, Nanjing, 210029, China.
Chih-Wen PaiFrankel Cardiovascular Center, University of Michigan, Ann Arbor, MI, 48109, USA.
Thomas G GleasonCardiovascular Surgery, Asheville Heart, Asheville, NC, 28801, USA.
Himanshu J PatelFrankel Cardiovascular Center, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0001-7639-2416
Kim A EagleFrankel Cardiovascular Center, University of Michigan, Ann Arbor, MI, 48109, USA.
Derek R BrinsterDepartment of Cardiovascular & Thoracic Surgery, Northwell Health, Manhasset, NY, 11103, USA.

Funding

Mardigian FoundationUM Faculty Group Practice; Terumo; and Ann and Bob Aikens
6 · The paper itself

Abstract

objectivesMost ascending aortic replacements for acute type A aortic dissection (ATAAD) are performed utilizing hypothermic circulatory arrest with an "open" distal anastomosis ("hemiarch"), whereas some are completed without ever removing the aortic cross-clamp. We sought to determine the impact of distal anastomotic technique in ascending aortic replacement for ATAAD repair.

methodsAll patients in the IRAD Interventional Cohort database who underwent ATAAD repair between 2010 and 2020 were identified (n = 2559). Data for distal anastomotic technique were available in 2031 patients who underwent ascending aortic replacement, divided into 2 groups, based on whether they underwent hypothermic circulatory arrest (Clamp Off, n = 1900 [93.5%]) or not (Clamp On, n = 131, [6.5%]). We then propensity-matched 101 pairs of patients and analysed operative data and short- and mid-term outcomes.

resultsIn-hospital mortality for the unmatched population was 13.1% (266 deaths), not statistically different between the matched groups (Clamp Off, 11.0% vs Clamp On, 5.1% P = .22). There were no statistically significant differences observed in 3-year post-discharge survival curves between matched cohorts (Clamp Off, 89.5% vs Clamp On, 90.4%; stratified log-rank P-value = .46). Major perioperative complications (renal failure requiring dialysis, reoperation for bleeding, respiratory insufficiency) were not significantly different between the groups, notably including stroke (Clamp Off, 10.2% vs Clamp On, 5.8%, P = .32).

conclusionsIn this propensity-matched cohort, postoperative mortality, major morbidity, and mid-term survival were comparable between open distal anastomosis and clamp-on strategies in selected patients undergoing ascending aortic replacement for ATAAD.

Indexed as

AortaAortic DissectionBlood Vessel Prosthesis ImplantationDissection, Ascending AortaAcute DiseaseAgedAnastomosis, SurgicalConstrictionFemaleHospital MortalityHumansMaleMiddle AgedPostoperative ComplicationsRetrospective StudiesTreatment Outcomeaortaaortic dissectioncirculatory arrest

Identifiers

PMID41934110
PMCPMC13099637

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.