Evidence map›Paper›PMID 41934103›Full record

ArticleGlia2026

RXR Gamma Enables Oligodendrocyte Differentiation by Suppressing Sonic Hedgehog Signaling.

Vito Antonio Baldassarro, Quentin Brassart, Valérie Fraulob, Laura Calzà, Wojciech Krezel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Glia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The Therapeutic Potential of Purmorphamine Across Disease Models.Journal of cellular and molecular medicine · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Vito Antonio BaldassarroInstitut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique UMR 7104, Institut national de la santé et de la recherche médicale U 1258, Illkirch, Université de Strasbourg, Strasbourg, France.ORCID 0000-0003-1020-4261
Quentin BrassartInstitut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique UMR 7104, Institut national de la santé et de la recherche médicale U 1258, Illkirch, Université de Strasbourg, Strasbourg, France.
Valérie FraulobInstitut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique UMR 7104, Institut national de la santé et de la recherche médicale U 1258, Illkirch, Université de Strasbourg, Strasbourg, France.
Laura CalzàDepartment of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.ORCID 0000-0002-4426-8477
Wojciech KrezelInstitut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique UMR 7104, Institut national de la santé et de la recherche médicale U 1258, Illkirch, Université de Strasbourg, Strasbourg, France.ORCID 0000-0003-1605-3185

Funding

Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques Role of RXRg in T3-mediated oligodendrocyte differentiation
6 · The paper itself

Abstract

Overcoming remyelination failure is one of the main targets in therapeutic strategies for multiple sclerosis. This process requires the differentiation of oligodendrocyte precursor cells (OPCs) to mature myelinating oligodendrocytes (OLs), a process known to be controlled by thyroid hormone, nuclear receptors, and sonic hedgehog (SHH). Retinoid X receptor gamma (RXRg) is one of the nuclear receptors acting as a positive regulator of remyelination, but little is known about its mechanisms of function. Using transcriptomic and pharmacological analysis of primary neural stem cell-derived OPCs, we show that RXRg is involved in the induction of the thyroid hormone-driven differentiation process and in refining it toward an oligodendrogenic cell fate. RXRg also emerged as an important negative modulator of SHH expression and signaling, as Shh and additional genes from this pathway were found to be strongly upregulated in Rxrg

Indexed as

Cell DifferentiationHedgehog ProteinsOligodendrogliaRetinoid X Receptor gammaSignal TransductionAnimalsCells, CulturedMiceMice, KnockoutNeural Stem CellsOligodendrocyte Precursor CellsPyridinesPyrimidinesVeratrum AlkaloidscyclopamineGANT 61Hedgehog ProteinsPyridinesPyrimidinesRetinoid X Receptor gammaShh protein, mouseVeratrum Alkaloidsoligodendrocyte progenitorsoligodendrogenesisretinoid X receptorssonic hedgehogthyroid hormone

Identifiers

PMID41934103
PMCPMC13049363

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.