Evidence map›Paper›PMID 41934042›Full record

ReviewTrends in neurosciences2026

Cellular and molecular mechanisms of astrocyte plasticity in learning and memory.

Leanne M Holt, Eric J Nestler, Michelle L Olsen

Abstract readReview
In one paragraph

Review in Trends in neurosciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Leanne M HoltNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Center for Substance Abuse Research, Neural Sciences Department, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA. Electronic address: leanne.holt@temple.edu.
Eric J NestlerNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Michelle L OlsenSchool of Neuroscience, Virginia Tech, Blacksburg, VA, USA. Electronic address: molsen1@vt.edu.

Funding

Transcription Factors in Stimulant and Opioid ActionP01DA047233 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ERIC J. NESTLER · 2019 to 2026
$16.5M
Epigenetic Mechanisms of Chronic Stress ActionR01MH129306 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ERIC J. NESTLER · 2023 to 2026
$2.7M
Training Program in Substance Use DisordersT32DA053558 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Paul J. Kenny · 2021 to 2026
$2.6M
TrkB.T1 signaling in astrocytesR01NS120746 · NINDS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI OLSEN, MICHELLE L · 2021 to 2025
$1.7M
Investigation of the Molecular Mechanisms Underlying Astrocytic CREB's Regulation of Cocaine Drug-SeekingK01DA062014 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI Leanne Holt · 2025 to 2026
$338k
NIDA NIH HHS K01 DA062014NIDA NIH HHS P01 DA047233NIDA NIH HHS T32 DA053558NIMH NIH HHS R01 MH129306NINDS NIH HHS R01 NS120746
6 · The paper itself

Abstract

Learning and memory arise from coordinated activity-dependent plasticity across neural circuits and brain regions. Astrocytes are increasingly recognized as active contributors to learning and memory via their roles in sensing, integrating, and responding to contextual information. Astrocytes modulate synaptic transmission, engage in circuit-specific signaling, and display context-dependent calcium dynamics that influence behavior. In this review, we focus on astrocyte functions across rodent models that display plasticity traditionally ascribed to neurons, including activity-dependent molecular and structural plasticity, circuit-level modulation, ensemble-like networks, and transcriptional, translational, proteomic, and epigenetic plasticity. Together, these findings redefine plasticity as an emergent property of the brain, regardless of cell type, in the context of learning and memory, and highlight the need for integrative, cell type-specific approaches to understanding complex behaviors.

Indexed as

AstrocytesBrainLearningMemoryNeuronal PlasticityAnimalsHumansbehaviorcalcium signalingcircuitsgene regulationgliasynaptic plasticity

Identifiers

PMID41934042
PMCPMC13051973

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.