Evidence map›Paper›PMID 41933992›Full record

ArticlePlacenta2026

Sound of nurturing: Advanced photoacoustic and ultrasound imaging of placental hemodynamics.

Van Tu Nguyen, Nanchao Wang, Liping Feng, Junjie Yao

Abstract read
In one paragraph

Article in Placenta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Van Tu NguyenDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Nanchao WangDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Liping FengDepartment of Obstetrics and Gynecology, Duke University, Durham, NC, USA. Electronic address: liping.feng@duke.edu.
Junjie YaoDepartment of Biomedical Engineering, Duke University, Durham, NC, USA. Electronic address: junjie.yao@duke.edu.

Funding

PFAS exposure is detrimental to placental function and fetal development by disrupting mitochondrial function and metabolismR01ES036951 · NIEHS · DUKE UNIVERSITY · PI FENG, LIPING · 2025 to 2025
$3.1M
3D real-time super-resolution cavitation mapping in laser lithotripsy of urinary stone diseaseR01DK139109 · NIDDK · DUKE UNIVERSITY · PI Michael E Lipkin, Junjie Yao · 2024 to 2026
$1.8M
NIDDK NIH HHS R01 DK139109NIEHS NIH HHS R01 ES036951
6 · The paper itself

Abstract

The placenta is a transient yet vital organ that regulates maternal-fetal exchange and profoundly influences pregnancy outcomes. Placental hemodynamic dysfunction is central to many major obstetric complications, including preeclampsia and fetal growth restriction. Despite advances in obstetric imaging, existing modalities such as Doppler ultrasound, magnetic resonance imaging, and X-Ray computed tomography remain limited in their ability to resolve placental microvasculature or quantify hemodynamics in vivo. Recent developments in photoacoustic (PA) and advanced ultrasound imaging have enabled assessment of placental vasculature, blood perfusion, and oxygenation with improved spatial and temporal resolution. Photoacoustic microscopy (PAM) and photoacoustic computed tomography (PACT) provide optical contrast derived from endogenous hemoglobin, offering functional insight into oxygen transport and vascular remodeling at various scales, while power Doppler (PWD), and ultrasound localization microscopy (ULM) deliver complementary blood flow and microvascular information at clinically-relevant depths. Integrating photoacoustic and ultrasound imaging allows for quantitative, multiscale visualization of placental hemodynamics from the macroscopic to the microscopic level. This review summarizes current progress in photoacoustic and ultrasound-based placental imaging, discusses different system implementations, reports important preclinical and clinical findings, and identifies remaining challenges in technical improvement and broad translation. Together, emerging photoacoustic and ultrasound imaging platforms promise to transform placental research and reproductive healthcare by enabling comprehensive, functional evaluation of maternal-fetal exchange in health and disease.

Indexed as

Advanced ultrasound imagingHemodynamicsHuman placentaMouse placentaPhotoacoustic imaging

Identifiers

PMID41933992
PMCPMC13273734

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.