Evidence map›Paper›PMID 41933682›Full record

ArticleBrain research2026

Mechanical properties of the developing brain in a model of fetal alcohol spectrum disorders and relationships to perineuronal net integrity.

L Tyler Williams, Katrina A Milbocker, Eva Smith, Cassandra P Bodner, Diego A Caban-Rivera, Matthew D J McGarry, Elijah E W Van Houten, Anna Y Klintsova, Curtis L Johnson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

L Tyler WilliamsDepartment of Biomedical Engineering, University of Delaware, Newark, DE 19716, USA.
Katrina A MilbockerDepartment of Biomedical Engineering, University of Delaware, Newark, DE 19716, USA; Department of Psychological & Brain Sciences, University of Delaware, Newark, DE 19716, USA.
Eva SmithDepartment of Psychological & Brain Sciences, University of Delaware, Newark, DE 19716, USA.
Cassandra P BodnerDepartment of Psychological & Brain Sciences, University of Delaware, Newark, DE 19716, USA.
Diego A Caban-RiveraDepartment of Biomedical Engineering, University of Delaware, Newark, DE 19716, USA.
Matthew D J McGarryThayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.
Elijah E W Van HoutenDepartement de Genie Mécanique, Universite de Sherbrooke, QC J1K 2R1, Canada.
Anna Y KlintsovaDepartment of Psychological & Brain Sciences, University of Delaware, Newark, DE 19716, USA.
Curtis L JohnsonDepartment of Biomedical Engineering, University of Delaware, Newark, DE 19716, USA; Department of Psychological & Brain Sciences, University of Delaware, Newark, DE 19716, USA. Electronic address: clj@udel.edu.

Funding

Subproject Title: Clinical Research Education, Mentoring and Career Development CoreU54GM104941 · NIGMS · UNIVERSITY OF DELAWARE · PI Susan Poland Giancola · 2013 to 2026
$60.5M
Vivarium CoreP30GM145765 · NIGMS · DELAWARE STATE UNIVERSITY · PI MELISSA A HARRINGTON · 2022 to 2026
$7.7M
High-Resolution, Anisotropic MR Elastography of the BrainR01EB027577 · NIBIB · UNIVERSITY OF DELAWARE · PI BAYLY, PHILIP V, JOHNSON, CURTIS L · 2019 to 2022
$2.7M
Hippocampal-thalamo-prefrontal circuitry damage and therapeutic intervention in a model of FASDR01AA027269 · NIAAA · UNIVERSITY OF DELAWARE · PI KLINTSOVA, ANNA Y · 2019 to 2023
$2.0M
NIAAA NIH HHS R01 AA027269NIBIB NIH HHS R01 EB027577NIGMS NIH HHS P30 GM145765NIGMS NIH HHS U54 GM104941
6 · The paper itself

Abstract

Neuroimaging is a useful tool for examining altered neurodevelopmental trajectories in fetal alcohol spectrum disorders (FASD). FASD affects 1 in 20 infants in the United States with higher prevalence in specific regions across the globe. Advanced neuroimaging methods, such as volumetric morphometry and diffusion-weighted imaging, are critical for determining the effectiveness of interventions that support neurodevelopment in FASD. In this study, we introduce the use of magnetic resonance elastography (MRE), a cutting-edge neuroimaging technique used to measure the mechanical properties of brain tissue, to assess the impact of alcohol exposure and combined exercise and environmental complexity intervention on neurodevelopment in a rat model of FASD. Our results indicate that brain stiffness is reduced in juvenile alcohol-exposed rats which is recovered to baseline by adulthood, and damping ratio increases in all rats with age. Additionally, we quantified cortical perineuronal net (PNN) density which follows similar trends to shear stiffness and damping ratio, suggesting MRE may be an effective method for noninvasively monitoring FASD progression related to extracellular matrix integrity.

Indexed as

BrainFetal Alcohol Spectrum DisordersAnimalsDisease Models, AnimalElasticity Imaging TechniquesEthanolFemaleMagnetic Resonance ImagingMaleNeurodevelopmentNeuroimagingPerineuronal NetsPregnancyRatsRats, Sprague-DawleyEthanolBrainFetal alcohol spectrum disordersImmunocytochemistryMagnetic resonance elastographyPerineuronal netsPreclinicalStiffness

Identifiers

PMID41933682
PMCPMC13154169

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.