Evidence map›Paper›PMID 41933636›Full record

ArticleHeart rhythm2026

Downregulation of L-type Ca

Marina Balycheva, Benedict Reilly-O'Donnell, Anita Alvarez-Laviada, Kelly Zhang, Marta Mazzola, Jose L Sanchez-Alonso, Carla Lucarelli, Roman Y Medvedev, Cristina E Molina, Sophie Schobesberger and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heart rhythm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Marina BalychevaNational Heart and Lung Institute, Imperial College London, United Kingdom; University of Verona, School of Medicine, Verona, Italy; Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin.
Benedict Reilly-O'DonnellNational Heart and Lung Institute, Imperial College London, United Kingdom.
Anita Alvarez-LaviadaNational Heart and Lung Institute, Imperial College London, United Kingdom.
Kelly ZhangDepartment of Biomedical Engineering Johns Hopkins University, Baltimore, Maryland.
Marta MazzolaNational Heart and Lung Institute, Imperial College London, United Kingdom; Humanitas Clinical and Research Center, Rozzano, Milan, Italy.
Jose L Sanchez-AlonsoNational Heart and Lung Institute, Imperial College London, United Kingdom.
Carla LucarelliNational Heart and Lung Institute, Imperial College London, United Kingdom; University of Verona, School of Medicine, Verona, Italy.
Roman Y MedvedevNational Heart and Lung Institute, Imperial College London, United Kingdom; University of Verona, School of Medicine, Verona, Italy; Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin.
Cristina E MolinaInstitute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; German Center for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany.
Sophie SchobesbergerNational Heart and Lung Institute, Imperial College London, United Kingdom.
Ivan DiakonovNational Heart and Lung Institute, Imperial College London, United Kingdom.
Peter T WrightNational Heart and Lung Institute, Imperial College London, United Kingdom; School of Life and Health Sciences, University of Roehampton, London, United Kingdom.
Claire E PouletNational Heart and Lung Institute, Imperial College London, United Kingdom.
Nadja I BorkInstitute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; German Center for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany.
Natalia A TrayanovaDepartment of Biomedical Engineering Johns Hopkins University, Baltimore, Maryland; Department of Medicine, Alliance for Cardiovascular Diagnostic and Treatment Innovation, Johns Hopkins University, Baltimore, Maryland.
Giuseppe FaggianUniversity of Verona, School of Medicine, Verona, Italy.
Prakash PunjabiNational Heart and Lung Institute, Imperial College London, United Kingdom; Department of Cardiothoracic Surgery, Hammersmith Hospital, National Heart and Lung Institute, Imperial College London, United Kingdom.
Viacheslav O NikolaevInstitute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; German Center for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany.
Alexey V GlukhovDepartment of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin. Electronic address: aglukhov@medicine.wisc.edu.
Julia GorelikNational Heart and Lung Institute, Imperial College London, United Kingdom. Electronic address: j.gorelik@ic.ac.uk.

Funding

Functional Microdomains in the Heart's Pacemaker: A New Dimension of Cardiac RemodelingR01HL141214 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Alexey V Glukhov · 2018 to 2026
$3.8M
Multiomics and Functional Characterization Establish Druggable Targets for PVC-Driven Idiopathic VFR01HL170521 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Lee Lochbaum Eckhardt, Eleonora Grandi · 2023 to 2026
$3.1M
Exploration of Arrhythmogenic Triggers and Substrates in Heart FailureR01HL126802 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI EFIMOV, IGOR R, GORELIK, JULIA · 2016 to 2019
$2.8M
KCNJ2-Induced Arrhythmia Mechanisms in CPVT and Heart Failure.R01HL139738 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI ECKHARDT, LEE LOCHBAUM · 2018 to 2021
$1.5M
Neutral sphingomyelinase in the mechanical regulation of the heartR01HL182084 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Lee Lochbaum Eckhardt, Alexey V Glukhov · 2025 to 2026
$1.2M
British Heart Foundation 12/18/30088; RG/17/13/33173; PG/17/3/32722NHLBI NIH HHS R01 HL126802NHLBI NIH HHS R01 HL139738NHLBI NIH HHS R01 HL141214NHLBI NIH HHS R01 HL170521NHLBI NIH HHS R01 HL182084Wellcome TrustWellcome Trust WT090594
6 · The paper itself

Abstract

backgroundAtrial fibrillation (AF) is associated by alterations in cardiomyocyte membrane microdomain organization that can modify the distribution and biophysical properties of L-type Ca

objectiveThis study aimed to examine the role of cellular microarchitecture and microdomain-specific changes of single LTCCs in I

methodsRight atrial (RA) and left atrial (LA) biopsies from patients in sinus rhythm (SR, n = 51) and AF (n = 61) were analyzed to assess cardiomyocyte microarchitecture and microdomain-specific remodeling of single LTCCs and I

resultsIn AF, I

conclusionI

Indexed as

Atrial FibrillationCalcium Channels, L-TypeHeart AtriaIon Channel GatingMembrane MicrodomainsMyocytes, CardiacCaveolin 3Down-RegulationFemaleHumansMaleMiddle AgedCalcium Channels, L-TypeCaveolin 3AtriaAtrial fibrillationCalcium channelCardiomyocyteCaveolin-3Scanning ion conductance microscopy

Identifiers

PMID41933636
PMCPMC13235752

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.