Evidence map›Paper›PMID 41933608›Full record

Observational studyChest2026

Association Between Admission Eosinophil Count and Hospital Resource Use in Community-Acquired Pneumonia: A Prospective Multicenter Study.

Barbara Christine Weckler, Qiong Wu, Wilhelm Bertrams, Max Kutzinski, Rieke Reiter, Saeed A Khan, Peter Ahnert, Norbert Suttorp, Martin Witzenrath, Christian Wildberg and 10 more

Registry-linked trialAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Chest, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02139163 (Epidemiological Study on Community Acquired Pneumonia), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02139163 recruitingnot on this map

Epidemiological Study on Community Acquired Pneumonia

Typeobservational_patient_registrySponsorCapnetz StiftungRan2002 to 2028Enrolled20,000ConditionsCommunity Acquired Pneumonia
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Barbara Christine WecklerDepartment of Respiratory, Intensive Care, and Sleep Medicine, Clinic for Respiratory Infections, Marburg University, Marburg, Germany; Institute for Lung Research, Universities of Giessen and Marburg Lung Center (UGMLC), Marburg University, Marburg, Germany. Electronic address: barbara.weckler@uni-marburg.de.
Qiong WuInstitute for Medical Biometry and Statistics, Marburg University, Marburg, Germany.
Wilhelm BertramsInstitute for Lung Research, Universities of Giessen and Marburg Lung Center (UGMLC), Marburg University, Marburg, Germany.
Max KutzinskiDepartment of Respiratory, Intensive Care, and Sleep Medicine, Clinic for Respiratory Infections, Marburg University, Marburg, Germany; Institute for Lung Research, Universities of Giessen and Marburg Lung Center (UGMLC), Marburg University, Marburg, Germany.
Rieke ReiterInstitute of Laboratory Medicine, Marburg University, Marburg, Germany.
Saeed A KhanDepartment of Geography, Marburg University, Marburg, Germany.
Peter AhnertInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany; German Center for Lung Research (DZL), Leipzig, Germany.
Norbert SuttorpDepartment of Infectious Diseases, Respiratory Medicine and Critical Care, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; German Center for Lung Research (DZL), Berlin, Germany; CAPNETZ STIFTUNG, Hannover, Germany.
Martin WitzenrathDepartment of Infectious Diseases, Respiratory Medicine and Critical Care, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; German Center for Lung Research (DZL), Berlin, Germany; CAPNETZ STIFTUNG, Hannover, Germany.
Christian WildbergDepartment of Infectious Diseases, Respiratory Medicine and Critical Care, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Mathias W PletzCAPNETZ STIFTUNG, Hannover, Germany; Institute for Infectious Diseases and Infection Control and Center for Sepsis Care and Control, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany.
Jan RuppCAPNETZ STIFTUNG, Hannover, Germany; Infectious Diseases Clinic and Institute of Medical Microbiology, University Hospital Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.
Ulrich M ZisslerTechnology Transfer Center for Building Biology, Airway and Indoor Health, Rosenheim Technical University of Applied Sciences, Freilassing, Germany; Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Marburg University, German Center for Lung Research (DZL), Universities of Giessen and Marburg Lung Center (UGMLC), Marburg, Germany; Department of Pediatrics, Klinikum rechts der Isar, School of Medicine, Technical University of Munich (TUM), Germany.
Timm GreulichDepartment of Respiratory, Intensive Care, and Sleep Medicine, Marburg University, Marburg, Germany; German Center for Lung Research (DZL), Marburg, Germany.
Thomas BrennerDepartment of Geography, Marburg University, Marburg, Germany.
Peter AlterDepartment of Respiratory, Intensive Care, and Sleep Medicine, Marburg University, Marburg, Germany; German Center for Lung Research (DZL), Marburg, Germany.
Gernot RohdeCAPNETZ STIFTUNG, Hannover, Germany; Department of Respiratory, Intensive Care, and Sleep Medicine, Marburg University, Marburg, Germany; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL).
Claus Franz VogelmeierDepartment of Respiratory, Intensive Care, and Sleep Medicine, Marburg University, Marburg, Germany; German Center for Lung Research (DZL), Marburg, Germany.
Andreas MayrInstitute for Medical Biometry and Statistics, Marburg University, Marburg, Germany.
Bernd SchmeckDepartment of Respiratory, Intensive Care, and Sleep Medicine, Clinic for Respiratory Infections, Marburg University, Marburg, Germany; Institute for Lung Research, Universities of Giessen and Marburg Lung Center (UGMLC), Marburg University, Marburg, Germany; German Center for Lung Research (DZL), Marburg, Germany; Core Facility Flow Cytometry - Bacterial Vesicles, Marburg University, Marburg, Germany; Institute for Lung Health (ILH), Giessen, Germany; German Center of Infectious Disease Research, Marburg, Germany; Center for Synthetic Microbiology (Synmikro), Marburg University, Marburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEosinopenia has been associated with adverse outcomes in community-acquired pneumonia (CAP). However, its relationship with hospital resource use remains unclear. RESEARCH QUESTION: What is the association between admission eosinophil counts and hospital resource use among adults with CAP? STUDY DESIGN AND

methodsThis prospective multicenter cohort study (Community-Acquired Pneumonia Network of Competence [CAPNETZ]; Identifier: 2024-07-11-CHV6) has enrolled patients ≥ 18 years of age with CAP in university hospitals in Germany since 2017. Associations between admission blood eosinophil counts and hospital resource use-ICU admission, mechanical ventilation, and length of stay-were assessed using multivariable regression models. The optimal eosinophil count threshold for stratifying patients by ICU admission and mechanical ventilation rates was identified, and outcomes were compared between patients above and below this threshold.

resultsLower eosinophil counts at admission were associated with increased ICU admission (n = 1,639; P < .001), including among patients treated with systemic glucocorticoids (P = .002) and those not receiving glucocorticoids (P = .047). Lower eosinophil counts also were associated with higher rates of mechanical ventilation (P = .014) and longer hospital stays (P = .024). An eosinophil count threshold of 10 cells/μL was identified as the cutoff that best distinguished patients with higher vs lower risk of ICU admission and mechanical ventilation. Patients with eosinopenia (≤ 10 cells/μL) showed higher ICU admission rates (14.2% vs 8.5%; P < .001; adjusted OR, 1.78), increased mechanical ventilation rates (9.1% vs 5.2%; P = .003; adjusted OR, 1.82), and longer hospitalization (mean, 10.2 days vs 9.0 days; P = .013).

interpretationOur results show that admission eosinopenia (≤ 10 cells/μL) was associated with greater hospital resource use and may serve as a practical biomarker for health care resource planning. CLINICAL

trial registrationGerman Clinical Trials Register; No.: DRKS00005274; URL: https://drks.de/.

Indexed as

Community-Acquired PneumoniaEosinophilsAgedCommunity-Acquired InfectionsFemaleGermanyHospitalizationHumansIntensive Care UnitsLength of StayLeukocyte CountMaleMiddle AgedProspective StudiesRespiration, Artificialbiomarkereosinophil counthealth care resourcespneumonia

Identifiers

PMID41933608
PMCPMC13494433

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.