Evidence map›Paper›PMID 41933353›Full record

ArticleJournal of nanobiotechnology2026

Enzyme-mimetic nanodots catalytically alleviate stress-induced hypertension via anti-neuroinflammation effects.

Jiayi Xu, Liang Chen, Zhangyan Ren, Rui Guo, Chen Yu, Wei Guo, Dongshu Du, Yu Chen

Abstract read
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jiayi Xu *School of Life Sciences, Shanghai University, Shanghai, 200444, China.
Liang Chen *School of Life Sciences, Shanghai University, Shanghai, 200444, China.
Zhangyan RenSchool of Life Sciences, Shanghai University, Shanghai, 200444, China.
Rui GuoDepartment of Clinical Medicine, Heze Medical College, Heze, 274000, Shandong, China.
Chen YuDepartment of Integrated TCM & Western Medicine, The Affiliated Cancer Hospital of Nanjing Medical University and Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing, 210009, China. 41186709@qq.com.
Wei GuoCollege of Life Sciences, Dezhou University, Dezhou, 253023, Shandong, China. guowei_shu@126.com.
Dongshu DuSchool of Life Sciences, Shanghai University, Shanghai, 200444, China. dsdu@shu.edu.cn.
Yu ChenSchool of Life Sciences, Shanghai University, Shanghai, 200444, China. chenyuedu@shu.edu.cn.

Funding

National Natural Science Foundation of China 32071111Natural Science Foundation of Shandong Province ZR202112030301
6 · The paper itself

Abstract

Stress-induced hypertension (SIH), driven by reactive oxygen/nitrogen species (ROS/RNS) accumulation and neuroinflammation in the rostral ventrolateral medulla (RVLM), lacks effective targeted therapies. Here, we synthesize ultrasmall manganese-doped carbon dots (Mn@CDs) (~ 2.5 nm) with multienzyme-mimetic activities, including superoxide dismutase, catalase, and peroxidase. Mn@CDs enable effective scavenging of diverse types of ROS/RNS, thereby protecting rat neuroblastoma B104 and microglial GMI-R1 cells from H

Indexed as

Anti-Inflammatory AgentsHypertensionNeuroinflammatory DiseasesAnimalsApoptosisCarbon Quantum DotsCatalaseCytokinesHydrogen PeroxideMaleMicrogliaOxidative StressRatsReactive Oxygen SpeciesSuperoxide DismutaseAnti-Inflammatory AgentsCatalaseCytokinesHydrogen PeroxideReactive Oxygen SpeciesSuperoxide DismutaseHypertensionInflammationNanocatalytic therapyNanodotsReactive oxygen species

Identifiers

PMID41933353
PMCPMC13173716

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.