ArticleBMC nephrology2026
Intestinal microbiome and acute transplanted kidney rejection - results of a single-center, case-control study.
Article in BMC nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundKidney transplantation (KTx) is the preferred form of renal replacement therapy. Acute rejection of the transplanted kidney (AR) may impair long-term outcomes. The gut microbiota influences immune system activity; however, its relationship with AR remains underexplored. This study aimed to investigate the relationship between the gut microbiome and risk of AR shortly after KTx.
methodsIn this single-center, retrospective case-control study, 10 patients with consecutive biopsy-proven AR shortly after KTx (median age 43 (38, 48) years) were matched by sex and age with 20 patients without AR (median age 42 (37, 48) years) during a one-year follow-up after KTx. Stool samples were collected 4–7 days after KTx for microbiome analysis using Illumina shallow shotgun sequencing. Bioinformatics analysis included taxonomic and functional profiling, with predictive modeling performed using a random forest model (RF). Model performance was evaluated using receiver operating characteristic (ROC) curves and the area under the curve (AUC).
resultsNo significant differences in gut microbiota diversity were observed between the groups. The differential abundance analysis did not identify any taxonomic features that remained significant after adjusting for possible covariates. The predictive RF models varied in performance, with functional KEGG pathway profiles showing the highest predictive value (AUC = 0.73). Key metabolic pathways implicated in such profiles included lipid metabolism, glycan biosynthesis and metabolism, and terpenoid and polyketide metabolism.
conclusionNo universal taxonomic gut microbiota markers for AR have been identified. The functional profile of the gut microbiome may be related to AR with specific metabolic pathways potentially involved in the underlying mechanisms. These findings suggest a role of immunomodulation, inflammation, and metabolic regulation in AR.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.