Trial reportInternational journal of obesity (2005)2026
An experimental investigation of the stigmatization of weight loss and regain from GLP-1 receptor agonist use and cessation.
Trial report in International journal of obesity (2005), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesGlucagon-like peptide-1 receptor agonist medications (GLP-1s) are effective for weight loss, but when people discontinue them, they tend to regain weight. The present work sought to examine the stigma of losing and regaining weight after GLP-1 use and cessation. SUBJECTS/
methodsIn two randomized, between-subjects experiments, participants evaluated a fictional target after reading a brief description of the target's weight-related history, which varied by study condition. Study 1 (N = 607) aimed to understand stigma directed at individuals who lose weight using GLP-1s, so the target was described as either: having lost weight by using a GLP-1, having lost weight via diet and exercise, or not having lost weight. Study 2 (N = 706) examined stigma directed at people who regain weight after discontinuing GLP-1s, and the target was described as either: having regained weight after discontinuing a GLP-1, having regained weight after discontinuing a diet and exercise plan, not having lost weight, or having maintained weight loss. After reading, participants completed measures of weight-related stereotyping and willingness to affiliate with the target.
resultsIn Study 1, the GLP-1 target was evaluated more negatively than the diet/exercise target and the no weight loss target. Participants' willingness to affiliate differed significantly across groups (p < 0.001), with the GLP-1 target receiving significantly lower ratings compared to the diet/exercise target (Mean difference = 0.52, 95% CI [0.27, 0.76]) and the no weight loss target (Mean difference = 0.26, 95% CI [0.02, 0.51]). In Study 2, the GLP-1 and diet/exercise targets were evaluated similarly, and both were rated more negatively than the target who maintained weight loss (ps ≤ 0.001).
conclusionsThese findings suggest that people may face stigma across the cycle of losing and regaining weight after using a GLP-1, underscoring the need for stigma-reduction efforts in the context of weight management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.