Evidence map›Paper›PMID 41933199›Full record

ArticleNature microbiology2026

Lipid accumulation in tuberculosis granulomas inhibits macrophage-CD4

Qiyao Chai, Zhe Lu, Min Zhao, Shanshan Yu, Yanzhao Zhong, Changgen Qiu, Zehui Lei, Yingxu Fang, Bing-Xi Li, Lingqiang Zhang and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. The lung tissue environment inbioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Aquatic virus transmission to humans.Nature microbiology · 2026
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Qiyao Chai *Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.ORCID http://orcid.org/0000-0002-0454-7834
Zhe Lu *Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Min Zhao *Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Shanshan Yu *Department of Bacteriology and Immunology, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research institute, Beijing, China.
Yanzhao ZhongKey Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Changgen QiuKey Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Zehui LeiKey Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Yingxu FangKey Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Bing-Xi LiKey Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Lingqiang ZhangState Key Laboratory of Medical Proteomics, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China.
Shuo WangKey Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China. wangshuo@im.ac.cn.ORCID http://orcid.org/0000-0002-5383-3386
Yu PangDepartment of Bacteriology and Immunology, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research institute, Beijing, China. py@bjxkyy.cn.ORCID http://orcid.org/0000-0001-6803-9807
Jing WangKey Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China. wangj6@im.ac.cn.ORCID http://orcid.org/0000-0001-5901-0797
Cui Hua LiuKey Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China. liucuihua@im.ac.cn.ORCID http://orcid.org/0000-0002-8035-7792

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32530001, 82330069National Natural Science Foundation of China (National Science Foundation of China) 82472296 and 82171744
6 · The paper itself

Abstract

Granulomas form to contain Mycobacterium tuberculosis (Mtb) infection in the lung. What constitutes protective or detrimental responses is poorly understood. Here, using spatial transcriptomics and immunofluorescence microscopy of human lung samples and mouse models, we characterize the spatial structure and transcriptome of macrophage and T cell populations in tuberculosis granulomas. We identify signatures of reduced major histocompatibility complex (MHC) class II levels on macrophages and reduced CD4

Indexed as

CD4-Positive T-LymphocytesGranulomaLipid MetabolismMacrophagesMycobacterium tuberculosisTuberculosisAnimalsCholesterolDisease Models, AnimalFemaleHistocompatibility Antigens Class IIHumansLungLysosomesMiceMice, Inbred C57BLCholesterolHistocompatibility Antigens Class II

Identifiers

PMID41933199

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.